吸入支气管扩张剂对重度COPD稳定期IC变化的意义  

Significance of IC Changes in Patients with Severe Stable COPD after Inhaled Bronchodilators

作　　者：昝海峰[1] 陶绍华[1] 官和立[1] 

机构地区：[1]成都大学附属医院,四川成都610081

出　　处：《现代临床医学》2014年第1期40-41,43,共3页Journal of Modern Clinical Medicine

基　　金：四川省卫生厅科研项目(编号:100075)

摘　　要：目的:探讨对重度慢性阻塞性肺疾病(COPD)稳定期患者吸入支气管扩张剂后检测深吸气量(IC)的临床意义。方法:对入选的50例重度慢性阻塞性肺疾病(COPD)稳定期患者,吸入沙丁胺醇前后,肺功能检测1 s用力呼气量(FEV1)、用力肺活量(FVC)、IC,测量6 min行走距离(6MWD)指标,比较用药前后各变量的变化及肺功能IC与6MWD的相关性。结果:用药后IC较用药前比较增加(P<0.05),6MWD用药后较用药前有提高(P<0.05)。回归分析显示IC的变化(△IC)与6MWD的变化(△6MWD)相关性较强(P<0.05,r=0.792 6)。结论:重度COPD稳定期患者吸入支气管扩张剂治疗前后IC的变化与运动耐力的变化相关性强,IC的测定较FEV1更能评价COPD患者的疗效。Objective： To explore the significance of bronchodilator on inspiratory capacity （IC） in patients with severe stable chronic obstructive pulmonary disease （COPD）. Methods：50 patients with severe stable COPD were selected. Before and after salbutamol inhalation, there were the pulmonary function test of a second forced expiratory volume （ FEV1 ）, forced vital capacity （ FVC ）, inspiratory capacity （ 1C ） ; and measured 6 minutes walk distance （6MWD）, compared to the variables before and after treatment, statistically analysed the correlation between the IC and 6MWD. Resuits：IC increased after treatment more than before treatment （ P 〈 0.05 ）, 6MWD improved （ P 〈 0. 05 ） after treatment more than before treatment. Regression analysis showed that there was a strong correlation between IC changes （AIC） and 6MWD change （△6MWD） （P 〈 0.05, r = 0. 792 6 ）. Conclusions ： There is a good correlation between the IC and 6MWD after using bronchodilator;the IC is better than FEV1 on evaluating the effect of treating COPD.

关 键 词：深吸气量 慢性阻塞性肺疾病 支气管扩张剂 

分 类 号：R563[医药卫生—呼吸系统]