浦氏纤维对心室电传导系统影响的仿真研究  

Simulation Research on the Effect of Purkinje Fiber on Ventricular Electrical Conduction

作　　者：宋俊雅[1] 袁永峰[1] 王宽全[1] 

机构地区：[1]哈尔滨工业大学计算机科学与技术学院,哈尔滨150001

出　　处：《智能计算机与应用》2014年第1期78-82,共5页Intelligent Computer and Applications

基　　金：国家自然科学基金(61001167;61173086;61179009)

摘　　要：浦肯野氏纤维在保证心室肌同步有序列的收缩中起着重要作用,在许多情况下被认为是严重室性心律失常发生的源头。为了探索性地研究浦肯野氏纤维的宽度对心室电传导系统的影响,建立了人的包含浦肯野氏纤维的心室电传导系统计算模型来模拟不同宽度下电兴奋在心室组织中的传导过程。仿真结果发现,当浦肯野氏纤维的宽度增加时,其传导电兴奋的驱动能力增大,进而引起心室肌组织中电兴奋的传导速率的增大。本模型对心律失常诱发机制研究提供了新的研究手段,还可以用来更加深入地研究浦肯野氏纤维-心室肌耦合连接机制,具有重大的理论和实践意义。Purkinjc fiber plays an important role in ensuring the synchronized timing and sequencing of ventricular contrac- tion, and it is considered as the source of serious ventricular arrhythmia in many conditions. An idealized 2D computational model of vcntricular electrical conduction which contains Purkinje fiber is established to simulate the excitation conduction in the cardiac tissue. Simulated results show that the driving ability of Purkinje fibers increases along with the increase of the Purkinjc fiber＇s width, and consequently increase the conduction velocity of ventrieular muscle. This model provides a new method to research the mechanism of arrhythmia and also can be used to study Purkinje - Ventricular junction mecha- nism. So the research of this subject is of significance in theory research and practical appiication.

关 键 词：浦肯野氏纤维 心室电传导系统 电兴奋传导速率 心律失常 

分 类 号：TP391.9[自动化与计算机技术—计算机应用技术]