类风湿性关节炎患者自身抗体的检测及应用  

Autoantibodies tests for patients with rheumatoid arthritis and their application

作　　者：董旭才[1] 张婧[1] 沈建军[1] 张静[1] 张惠中[1] 

机构地区：[1]唐都医院检验科,陕西西安710038

出　　处：《国际检验医学杂志》2014年第4期406-407,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨抗核抗体（ANA）检测在类风湿性关节炎（RA）诊断中的意义。方法随机选取该院2010～2013年收治的RA患者67例，以间接免疫荧光法及免疫印迹发检测ANA，以速率散射免疫比浊法检测类风湿因子（RF），并分析ANA和RF在诊断RA中的相关性。结果检测ANA有利于RA的诊断。67例标本中抗-nRNP／Sm、抗-SS-A、抗一组蛋白阳性率最高，分别为21％、18％、18％。RA组ANA核型主要为均质型，其次为颗粒型，也有部分为阴性。结论临床上治疗RA患者时，应注意监测是否同时患有多重自身免疫性疾病。To Study the significance of detecting antinuclear antibody in rheumatoid arthritis （RA）. Methods 67 ca- ses of RA patients in our hospital between 2010-2013 were selected. Indirect immunofluorescence and Western blotting were a- dopted to detect antinuclear antibody （ANA）,and immuneturbidimetric method was adopted to detect RF, then the correlation be- tween ANA and RF and the diagnosis of RA was analyzed. Results Detection of ANA is helpful to diagnosis of RA. The positive rates of anti-nRNP/Sm, anti-SS-A, anti-histone were 21%. 18%. 18%. Homogeneous pattern is the most dominated phenotype. Conclusion Attentions should be paid to monitor the clinical treatment of RA patients,especially those who suffers from multiple autoimmune diseases.

关 键 词：类风湿因子 抗体 抗核 关节炎 类风湿 

分 类 号：R593.22[医药卫生—内科学]