血清降钙素原、超敏C反应蛋白与冠状动脉粥样硬化病变程度的关系  

Relationship of combined detection of hs-CRP and PCT and degree of coronary atherosclerosis

作　　者：刘志祥[1] 谢飞[1] 吴玉竹[1] 李文兵[1] 

机构地区：[1]湖北医药学院附属太和医院检验科,湖北十堰442000

出　　处：《国际检验医学杂志》2014年第4期408-409,411,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨冠心病患者血清降钙素原（PcT）、超敏C反应蛋白（hs-CRP）水平与冠状动脉粥样硬化病变程度的关系。方法118例冠状动脉造影术患者分为冠心痛组（n—89）和冠状动脉造影正常组（对照组，n=29），冠心病组患者又根据Gensini评分系统分分为：〈30分组、30～60分组、〉60分组，分别检测各组的血清PCT和hs-CRP水平。结果冠心病组PCT和hs-CRP水平高于对照组（P〈O．05）；同时，冠心病组PCT和hs-CRP水平均与Gensini评分呈正相关（r分别为0．88、0．90，P〈0．05）。结论血清PCT、hs-CRP的水平与冠状动脉粥样硬化病变程度呈正相关，联合检测PCT和hs-CRP有助于早期诊断冠状动脉粥样硬化引起的冠心病。Objective To discuss the relationship between the degree of coronary atherosclerosis and the levels of hypersensitive C-reactive protein （hs-CRP） and procalcitonin （PCT）. Methods 118 individuals with coronary artery angiography were selected, including coronary heart disease group（n= 89） and normal control group （n= 29）. Coronary heart disease （CHD） patients were di- vided into three groups according to the Gensini score system：〈30 Group,30-60 Group and 〉60 Group. To compare the differ- ences between groups and its correlation with Gensini score,we detected the contents of hs-CRP and PCT. Results PCT arid hs- CRP levels in CHD patients are significantly higher than that of control group （P〈0.05）. At the same time,PCT and hs-CRP lev- els increase gradually with the increase of Gensini score,the correlation index are 0.88 and 0.90 （P〈0.05）. Conclusion PCT and hs-CRP levels are positively associated with the degree of atherosclerotic lesions. Combined detection of PCT and hs-CRP can early diagnose CHD caused by coronary artery atherosclerosis.

关 键 词：降钙素原 C反应蛋白质 冠状动脉粥样硬化 

分 类 号：R541.4[医药卫生—心血管疾病]