雷公藤倍半萜生物碱的研究  

STUDY OF SESQUITERPENE ALKALOIDS FROM TRIPTERYGIUM WILFORDII HOOK.F.

作　　者：林绥[1] 李援朝[2] 樱井信子 林建峰[1] 金静君[1] 

机构地区：[1]福建省医学科学研究所,福建福州350001 [2]中国科学院上海药物研究所,上海200031 [3]日本星药科大学

出　　处：《药学学报》2001年第2期116-119,共4页Acta Pharmaceutica Sinica

基　　金：福建省科委重点项目(99Z16)

摘　　要：目的　研究雷公藤 (TripterygiumwilfordiiHook .f .)的化学成分。 方法　应用各种色谱技术进行分离纯化 ,用UV ,IR ,MS ,HRMS ,1HNMR ,13CNMR(COM和OFR) ,1H 1HCOSY ,1H 13CCOSY ,2D NOESY ,1H 13CCOLOC鉴定化合物。并进行初步的药理实验。结果　分离并鉴定了 2个生物碱 :euonine (I)和雷公藤康碱 (IIwilfordconine)。结论　II为一种新的倍半萜生物碱 ,药理实验证明该生物碱有免疫抑制活性 。AIM To study the chemical composition of Tripterygium wilfordii Hook.f. METHODS Column chromatography was used to separate the chemical constituents. UV, IR, MS, HRMS, 1HNMR , 13 CNMR (COM and OFR), 1H 1H COSY, 1H 13 C COSY, 2D NOESY and 1H 13 C COLOC were used to determine the structures of the isolated constituents. RESULTS Two sesquiterpene alkaloids were isolated and their structures were elucidated as euonine and wilfordconine on the basis of spectral evidence. CONCLUSION Wilfordconine, a new sesquiterpene alkaloid,was shown to be immunosuppressive.

关 键 词：雷公藤 倍半萜生物碱 euonine 雷公藤康碱 免疫抑制 

分 类 号：R284.1[医药卫生—中药学]