pH敏感型双模型介孔SiO_2的制备及其对布洛芬的缓控释性能  

Preparation of pH-Responsive Bimodal Mesoporous Silicas and Their Performances in Controlled Ibuprofen Delivery

作　　者：郭月月[1] 白诗扬[1] 孙继红[1] 

机构地区：[1]北京工业大学化学环境与能源工程学院,北京100124

出　　处：《石油学报（石油加工）》2014年第1期181-186,共6页Acta Petrolei Sinica(Petroleum Processing Section)

基　　金：国家自然科学基金(21076003);北京市属市管高等学校人才强教计划(PHR200907105005;PHR201107104;005000543111517和005000541211019/20)资助

摘　　要：通过两步法制备了pH敏感型聚合物葡聚糖(Dex)-聚丙烯酸(PAA)包裹的双模型介孔SiO2(BMMs)纳米复合材料(D-P/BMMs),并采用XRD、SEM、FT-IR、TG和N2吸附-脱附手段对其进行了结构表征。以布洛芬(IBU)为模型药物详细考察了D-P/BMMs对药物IBU的缓释及pH敏感控释性能。结果表明,BMMs介孔有序度由于Dex-PAA的包裹而降低;IBU在pH=7.4的磷酸盐缓冲溶液中的释放率达到46%,明显高于在pH=2.0中的释放率(约26%),说明D-P/BMMs具有较强的pH敏感性,是一种良好的药物控释载体。The pH-responsive bimodal mesoporous SiO2 nanocomposite （D-P/BMMs） was prepared via two-steps method,which was achieved by the combination of pH-responsive Dex-PAA polymer with the bimodal mesoporous silica （BMMs）.The structural characteristics and textural properties of the resultant D-P/BMMs were characterized by means of XRD,SEM,FT-IR,TG and N2 adsorption-desorption techniques,which demonstrated that the mesoporous ordered degree of BMMs was decreased because of coating of Dex-PAA polymer.Meanwhile,the pH-responsive drug-controlled delivery was systematically investigated by using ibuprofen as a model drug under phosphate buffer solutions （PBS） with different pH values,and the results showed that the releasing yield of ibuprofen was up to 46% at pH=7.4 more than that at pH=2.0 （around 26%）,suggesting that the D-P/BMMs nanocomposite has an excellent performance of pH-responsive drug delivery.

关 键 词：聚合物 双模型介孔材料(BMMs) 布洛芬 pH敏感释放 

分 类 号：TE122.14[石油与天然气工程—油气勘探]