颐年饮对家兔心肌缺血再灌注损伤的保护作用  

Protective Effects of Yinianyin on Myocardial Ischemia-Reperfusion Injury

作　　者：张压西[1] 曾亚男[1] 彭连生[1] 严启伟[1] 

机构地区：[1]武汉市中医医院研究所,武汉430051

出　　处：《中国药师》2001年第1期4-6,共3页China Pharmacist

摘　　要：目的:探讨不同剂量颐年饮对家兔心肌缺血,再灌注损伤的影响。方法:结扎家兔冠状动脉,再灌注。结果:颐年饮能明显降低再二醛(MDA)的含量,提高超氧化物歧化酶(SOD)、谷胱甘肽过氧化酶(GSH-Px)的活力,明显改善造模(型)家兔异常的心电图及心肌超微结构,与生理盐水组比较差异显著(P<0.05)。结论:颐年饮具有抗氧自由基和抗脂质过氧化作用,对心肌缺血具有良好的保护作用,且呈量效关系。Objectives: To explore the effects of Yinianyin( YNY) on myocardial ischemia-reperfusion injury in rabbits. Methods: Ligation of coronary artery and reperfusion in rabbits. Results: YNY 2g/kg, 4g/kg, 6g/kg could markedly reduce the malondialde-hyde(MDA), strengthen the activities of the superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), YNY could markedly improve model rabbits unusual EKG as well as myocardial microscopic structure. Conclusion: YNY acts as an effect of free radical scavenger and anti-lipid peroxidation, YNY exerts a good protective effect on myocardial ischema with a dose-effect relationship.

关 键 词：颐年饮 心肌缺血 再灌注损伤 家兔 中医药治疗 

分 类 号：R259.422[医药卫生—中西医结合] R285.5[医药卫生—中医内科学]