不同病情系统性红斑狼疮患者合并妊娠的临床特征及围生结局分析  

Clinical characteristics and perinatal outcomes of pregnant women with different conditions of systemic lupus erythematosus

作　　者：王慧 兰徐霞 张延珍[1] 

机构地区：[1]福建医科大学附属协和医院妇产科,福州350001

出　　处：《福建医药杂志》2014年第1期16-19,共4页Fujian Medical Journal

摘　　要：目的探讨不同病情系统性红斑狼疮(SLE)患者合并妊娠的临床特征及围生结局。方法回顾性分析47例SLE合并妊娠患者的临床资料,分为病情活动组(17例)和病情稳定组(30例),比较两组的临床资料。结果病情活动组分娩前病情重,累及脏器多,2例死亡。病情活动组子痫前期、胎儿生长受限、胎儿丢失及早产的发生率高于病情稳定组,差异均有统计学意义(均P<0.05)。病情活动组终止妊娠的孕周明显早于病情稳定组,新生儿体重明显低于病情稳定组,差异有统计学意义(均P<0.05)。病情活动组活产率为64.7%,提前终止妊娠多见,新生儿死亡率高达36.4%。结论 SLE患者妊娠病情活动者妊娠结局不良。Objective To discuss the clinical characteristics and perinatal outcome of pregnant women with different con- ditions systemic lupus erythematosus （SLE）. Methods The clinical data of 47 pregnant women＇with SLE were analyzed retro- spectively. Forty-seven gravidas with SLE were divided into the unstable group and the stable group. Results The condition of patients in unstable group was worse than the stable group before delivery. The patients of unstable group had serious organ- damage, and the cumulative organ, even two cases of pregnant women died. The incidence of preeclampsia, fetal growth re- striction, fetal loss and preterm birth were higher in the unstable group than those in the stable group, the difference was statis- tically significant （P〈0.05）. Neonatal mortality rate was higher, Live birth rate was lower, gestational age significantly was earlier and birth weight was lower in the unstable group than those in the stable group, the difference was statistically significant （P〈0. 05）. Conclusion Women with SLE have adverse perinatal outcome compared to women in stable conditions of SLE.

关 键 词：系统性红斑狼疮 妊娠 并发症 

分 类 号：R593.241[医药卫生—内科学] R714[医药卫生—临床医学]