舍曲林治疗急性心肌梗死后抑郁症患者的疗效观察  

Observation of the effect for sertraline on depressed patients after acute myocardial infarction

作　　者：陈天宝[1] 

机构地区：[1]福建省泉州市第一医院心内科,泉州362000

出　　处：《福建医药杂志》2014年第1期89-91,共3页Fujian Medical Journal

摘　　要：目的探讨舍曲林对急性心肌梗死患者合并抑郁的疗效。方法将70例急性心肌梗死合并抑郁的患者随机分为观察组(服用舍曲林组)和对照组(未服用舍曲林组),每组各35例,治疗6周。以汉密尔顿抑郁量表(HAMD)评定疗效,并观察心脑血管事件发生率。结果治疗6周后,两组HAMD评分数值都明显下降(P<0.05),观察组下降更明显(P<0.05),但心脑血管事件发生率差异无统计学意义(P>0.05)。结论舍曲林能改善急性心肌梗死患者的抑郁症状,并且不产生不良的心血管反应。Objective To examine the efficacy of sertraline on patients with depression after acute myocardial infarction （AMI）. Methods Depressed patients with AMI were randomly assigned to the control group （n=35） that received usual drugs and the treatment group （n=35） that received usual drugs and sertraline for six weeks. HAMD score was used to assess the ef- ficacy and the major adverse cardiocerebral events were measured. Results Compared to baseline, HAMD score was significant- ly decreased after six weeks in both control group and treatment group （P〈0. 05）. Compared with control group, the treat- ment group showed a significant reduction （P〈0.05）. There was no significant difference in the outcome of cardiocerebral e- vents between control group and treatment group （P〉0.05）. Conclusion Sertraline can control depressive symptoms in pa- tients with AMI, and doesn＇t increase the risk of adverse cardiovascular side effects.

关 键 词：舍曲林 急性心肌梗死 抑郁症 

分 类 号：R542.22[医药卫生—心血管疾病]