壬菌铜原药亚慢性毒性试验  

Subchronic Toxicity Test of Cuppric Nonyl Phenolsulfonate TC

作　　者：周艳丽[1,2] 张少锋[2] 杨萌[2] 薛超[2] 

机构地区：[1]西北农林科技大学植物保护学院,陕西杨凌712100 [2]西安近代化学研究所,西安710065

出　　处：《农药》2014年第3期203-205,共3页Agrochemicals

基　　金：国家重点新产品项目(2011TJG00007)

摘　　要：[目的]观察壬菌铜原药对大鼠的毒性作用和无作用剂量。[方法]将壬菌铜原药按0、2.5、25、250 mg/kg剂量分别拌入饲料内经口喂饲染毒90 d,观察大鼠外观体征、体质量、进食情况等。染毒结束进行血常规、血生化、脏器系数及病理组织学检测。[结果]高剂量组雌、雄性大鼠的体质量增长显著低于对照组。摄食受到抑制,血常规、血生化、尿液检查均未出现明显异常的指标改变。[结论]确定大鼠90 d亚慢性经口最大无作用剂量为2.5 mg/kg,推荐ADI值为0.002 5 mg/kg。[Aims] The toxicity effects of cuppric nonyl phenolsulfonate TC and no effect dose on rats were observed. [Methods] Cuppric nonyl phenolsulfonate TC were mixed into feed at the dose of 0, 2.5, 25, 250 mg/kg, then fed rats by 90 d through mouth, and signs appearance, weight, eating etc were observed. Finally, blood routine, blood biochemistry, organ coefficients and histopathology were detected. [Results] High dose group of female, male body weight was lower than the control group. Feeding was clearly constrained; blood routine, blood biochemistry examination and urine test had no obvious change. [Conclusions] 90 d rats subchronic oral maximum no effect dose is 2.5 mg/kg, and the ADI value is recommend to be 0.002 5 mg/kg.

关 键 词：壬菌铜原药 大鼠 亚慢性毒性 

分 类 号：TQ450.261[化学工程—农药化工]