氟比洛芬酯超前镇痛对骨科手术术后镇痛临床效果分析  

Effect of preemptive anaogesic of flurbiprofen axetil on postoperative pain relief after orthopedic surgery

作　　者：刘玉文[1] 

机构地区：[1]宜昌市中心人民医院检验科,湖北宜昌443003

出　　处：《临床和实验医学杂志》2014年第3期203-206,共4页Journal of Clinical and Experimental Medicine

摘　　要：目的 观察氟比洛芬酯用于骨科手术时超前镇痛的作用效果.方法 50例美国麻醉师协会（ASA）Ⅰ～Ⅱ级行骨科手术的患者,随机分为实验组Ⅰ组和对照组Ⅱ组,每组25例.术前15 min实验组（Ⅰ组）进行氟比洛芬酯100 mg的静脉缓注,对照组（Ⅱ组）进行生理盐水20 ml静脉缓注.分别记录术后1 h、2 h、4 h、6 h、8 h、12 h、24 h的视觉模拟评分（VAS）、24 h曲马多用量和不良反应,并在镇痛结束后统计患者对镇痛治疗的总体满意度.结果 术后1 h、2 h、4 h、6 h VAS Ⅰ组均低于Ⅱ组（P〈0.05）,术后8 h、24 h两组VAS无显著差异;术后24 hⅠ组（275.8±45.5）mg的曲马多用量明显低于Ⅱ组的（310.5±57.2）mg（P〈0.05）,不良反应方面两组差异无显著性.Ⅰ组与Ⅱ组患者总体满意度在Ⅱ级和Ⅳ级上差异明显（P〈0.05）.结论 氟比洛芬酯在骨科手术镇痛中的超前应用,能够减少曲马多用量,对术后镇痛有显著效果.Objective To observe the preemptive analgesic effect of flurbiprefen axetil on postoperative pain relief. Methods Fifty ASAⅠ -Ⅱ patients who were assigned to receive orthopaedic surgery were randomly divided into experimental group and control group, each group of 25 patients. Fifteen minutes before surgery, patients in experimental group received 100 mg of flurbiprofen grease by slow intravenous injection, while 20 ml of normal saline was given for patients in control group. 1 h, 2 h, 4 h, 6 h, 8 h, 12 h and 24 h after surgery, visual analogue scale （VAS） were evalu- ated respectively, and 24 h tramadol dosage and adverse reactions were recorded. The overall satisfaction of patients for analgesic therapy was statisti- cally analyzed. Results 1 h, 2 h, 4 h, 6 h after surgery, VAS in experimental group were lower than those in control group （ P 〈 O. 05 ）. The 24 h tramadol dosage （275.8 ±45.5 nag） in experimental group was significantly lower than that in control group （310.5 ± 57.2 rag） （ P 〈0.05）. There were significant differeneas in adverse reactions （except urinary retention） between two groups （ P 〈0.05）. There was also significant differ- ence in the overall satisfaction for analgesic therapy in levelll and 1V between two groups （ P 〈 O. 05）. Conclusion Preemptive analgesia of flurbi- prefen axetil can reduce the dosage of tramadol, alleviate the adverse reaction in nerve and gastrointestinal system, and has remarkable analgesic effect on postoperative pain relief.

关 键 词：骨科手术 超前镇痛 氟比洛芬酯 曲马多 

分 类 号：R614[医药卫生—麻醉学]