促孕原位凝胶灌注液的制备及其体外释放度  

Preparation of Fertility-promoting Intrauterine Infusion in situ Gel and Its in vitro Release

作　　者：卢朝成[1] 符华林[1] 周涛[1] 张艳丽[1] 刘梦娇[1] 金超[1] 曹航[1] 罗莉[1] 

机构地区：[1]四川农业大学动物医学院动物疫病与人类健康四川省重点实验室,四川雅安625014

出　　处：《过程工程学报》2014年第1期139-144,共6页The Chinese Journal of Process Engineering

基　　金：四川农业大学"优秀硕士论文培育基金"项目

摘　　要：以泊洛沙姆407(P407)和188(P188)为载体材料,采用冷溶法将促孕灌注液制成原位凝胶,考察了P407和P188浓度、羟丙基甲基纤维素浓度(HPMC)、海藻酸钠浓度及促孕灌注液对胶凝温度的影响,研究了体外溶蚀、体外释药特性.结果表明,P407浓度为18%(w)、P188浓度为7.5%(w)、HPMC浓度为0.3%(w)时,凝胶平均胶凝温度为27.9℃,6 h内平均体外累积溶蚀度和药物累积释放度分别为92.11%和95.42%,凝胶中的药物成分主要通过溶蚀方式释放,药物释放符合零级释药方程.Fertility-promoting intrauterine infusion in situ gel （FPG） was prepared by cold soluble method with Poloxamer 407 （P407） and Poloxamer 188 （P188）. The effects of concentrations of P407, P 188, hydroxy propyl methyl cellulose （HPMC） and sodium alginate on gelation temperature were studied, the gelation temperature of in situ gel before and after addition of fertility-promoting intrauterine infusion liquid and release behavior in vitro were investigated. The results showed that the average gelation temperature of FPG was 27.9℃ when the concentrations of P407, P188 and HPMC were 18%（ω）, 7.5%（ω） and 0.3%（ω）. Average accumulated loss rate of gel and accumulated release rate of drug were 92.11% and 95.42% in 6 h. The drug in the gel was released by the gel erosion, and the release profiles accorded to zero order equation.

关 键 词：促孕灌注液 原位凝胶 胶凝温度 体外溶蚀 体外释放 淫羊藿苷 

分 类 号：S859.53[农业科学—临床兽医学]