联合检测血清可溶性补体受体sCR1、胱抑素C、β2微球蛋白和尿微量白蛋白对糖尿病肾病的诊断价值  

Diagnostic value of combined detection of serum soluble complement receptor, Cystatin C, β2 mi-croglobulin and urinary albumin on diabetic nephropathy

作　　者：张婷兰[1] 李守勇[1] 陈维霞[1] 孙阳[1] 胡卫国[1] 

机构地区：[1]山东省枣庄市立医院检验科,277101

出　　处：《中国实用医刊》2014年第5期61-63,共3页Chinese Journal of Practical Medicine

摘　　要：目的检测糖尿病肾病患者血清可溶性补体受体sCR1、胱抑素c（CysC）、β2微球蛋白（β2MG）和尿微量白蛋白（mAlb）的水平，研究其水平变化在早期诊断中的临床意义，为糖尿病肾病的临床诊断和治疗提供依据。方法选择82例糖尿病肾病患者作为糖尿病肾病组，65例健康体检者作为正常对照组。采用ELISA法检测样本血清中sCR1的含量水平，采用免疫比浊法检测血清中CysC、B2MG及尿mAlb的水平。用统计学方法分析患者血清中sCR1、CysC、β2MG及尿mAlb水平和疾病的相关性。结果糖尿病肾病患者血清中sCR1水平低于正常对照组（P〈0．01）；CysC和B2MG在糖尿病肾病患者血清中含量高于正常对照组（P〈0．01）；糖尿病肾病患者晨尿中mAlb水平显著高于健康对照组（P〈0．01）。结论血清中sCR1在糖尿病肾病患者血清中显著降低，而CysC、p2MG及尿mAlb含量则显著升高，与糖尿病肾病的病情进展有重要相关性。因此，sCR1、CysC、β2MG和mAlb可作为检测病情活动的辅助监测指标。提示sCR1、CysC、β2MG和mAlb可能在糖尿病肾病患者发病中起重要作用。Objective To detect the levels of serum soluble complement receptor 1 （sCR1） , cystatin C（CysC） , β2 microglobulin（β2MG） and urine albumin（mAlb） in patients with diabetic nephropathy（ DN）, and study the effects of these factors on the diagnosis and treatment of diabetic nephropathy, in order to provide references for the early stage diagnosis and treatment of dia- betic nephroathy. Methods Eighty-two DN patients were selected were chose as the experiment group and 65 healthy people as the control group. The serum level of sCR1 was detected by ELISA. The serum levels of CysC, β2MG and mAlb were measured by immunoturbidimetry. Then, the correlation of serum levels of sCR1, CysC, β2MG and mAlb with DN was analyzed. Results The serum level of sCR1 of DN patients was lower than that of healthy people. The levels of CysC, β2MG in serum and mAlb were higher in DN patients than that in healthy people （ P 〈 0. 01 ）. Conclusions The serum levels of sCR1, CysC, β2 MG and mAlb are supplementary indicators for the progression of DN, suggesting that these factors may play an important role in the devel- opment of DN, so sCRI, cysc, β2MG and mAlb can be used as supplementary monitoring indexes for the progression of DN.

关 键 词：血清可溶性补体受体 胱抑素C Β2微球蛋白 微量白蛋白 

分 类 号：R587.2[医药卫生—内分泌]