中国南海隋氏蒂壳海绵Theonellaswinhoei的化学成分研究  

Studies on Chemical Constituents of Theonellaswinhoei from the South China Sea

作　　者：甘建红[1,2] 席达 于豪冰[2] 闵倩[1] 芶了 谢晶[1] 

机构地区：[1]上海海洋大学食品学院,上海水产品加工及贮藏工程技术研究中心,上海201306 [2]第二军医大学附属长征医院海洋药物研究室,上海200433 [3]第二军医大学附属东方肝胆医院微创外科2室,上海200438

出　　处：《天然产物研究与开发》2014年第2期209-211,共3页Natural Product Research and Development

基　　金：上海市科委工程中心建设:上海水产品加工及贮藏工程技术研究中心(11DZ2280300)

摘　　要：利用Sephadex LH-20凝胶柱层析、硅胶柱层析、HPLC等多种柱色谱手段对中国南海隋氏蒂壳海绵Theonellaswinhoei化学成分进行分离提纯;通过波谱解析结合文献对照,鉴定化合物的结构。从其正丁醇萃取部位首次分离鉴定了6个化合物:thymidine(1),thymidine-5'-carboxylic acidmethylester(2),thymidine-5'-carboxylic acid butyl ester(3),uracil(4),thymine(5),7,8-Dimethyl-iso-alloxazine(6)。Sephadex LH-20 columnchromatography, silica column chromatography and HPLC methods were used to iso- late and refine compounds from sponge Theonellaswinhoei from the South China Sea. The structures were identified by spectroscopic analysis and comparison with the literatures. From the n-BuOH soluble extract of Theonellaswinhoei, six compounds were isolated for the first time and their structures were determined as thymidine （ 1 ）, thymidine-5＇-carboxylie acid methyl ester（2） ,thymidine-5＇-earboxylie acid butyl ester（3）,uracil（4）,thymine（5）,7,8-Dimethyl-iso-alloxazine （6）.

关 键 词：海绵 化学成分 结构鉴定 

分 类 号：Q939.112[生物学—微生物学] R931.77[医药卫生—生药学]