抗肿瘤蕈类多糖的研究进展  

Review on Anti-tumor Polysaccharides in Mushroom

作　　者：汲晨锋[1,2] 岳磊[3] 

机构地区：[1]哈尔滨商业大学国家教育部抗肿瘤天然药物工程研究中心,黑龙江哈尔滨150076 [2]哈尔滨商业大学生命科学与环境科学研究中心,黑龙江哈尔滨150076 [3]哈尔滨工业大学生命科学与技术学院,黑龙江哈尔滨150006

出　　处：《林产化学与工业》2014年第1期128-134,共7页Chemistry and Industry of Forest Products

基　　金：黑龙江省青年科学基金项目(QC2011C100);中国博士后科学基金项目(2012M520761)

摘　　要：蕈类被视为功能性食物,具有营养和药用价值,多糖是蕈类中的主要活性物质,具有抗肿瘤和增强免疫的作用。蕈类多糖由于来源广泛,其在化学结构和抗肿瘤活性方面存在较大差异。文章从具有抗肿瘤活性的蕈类多糖、抗肿瘤蕈类多糖的结构特征、蕈类多糖结构与抗肿瘤活性的关系、蕈类多糖的抗肿瘤作用及机制4个方面综述了抗肿瘤蕈类多糖的研究进展。并进一步从多糖受体相关的信号转导通路研究、构效关系研究、代谢动力学研究3个方面进行了展望。Mushrooms are recognized as functional foods and have credible nutritional and medicinal values. Polysaccharide is one of the most bioactive components in mushrooms and exhibits anti-tumor and immunnstimulating activities. Numerous polysaccharides with anti-tumor activity have been extracted from a variety of mushrooms, but there are many differences in their chemical composition, structure and anti-tumor activity. This review aims to integrate the R＆D progress of anti-tumor polysaccharides in mushrooms which include mushroom polysaccharides with anti-tumor activity, chemistry of mushroom polysaccharides, relationship between structure and anti-tumor activities of mushroom polysaccharides, anti-tumor activity and mechanisms of mushroom polysaccharides. And this review also looks forward to the future studies on receptors and signal transduction pathway, structure activity relationship and pharmacokinetics of polysaccharides.

关 键 词：蕈类 抗肿瘤 多糖 研究 

分 类 号：TQ35[化学工程] Q935[生物学—微生物学]