秀丽隐杆线虫在抗感染研究中的应用  

Application of Caenorhabditis elegans in anti-infective research

作　　者：胡淦海 李德东[2] 赵兰雪[1,2] 王彦[2] 姜远英[2] 

机构地区：[1]福建中医药大学药学院中药学教研室,福建福州350108 [2]第二军医大学药学院新药研究中心,上海200433

出　　处：《药学实践杂志》2014年第1期5-8,共4页Journal of Pharmaceutical Practice

基　　金：国家自然科学基金(81273558;81072678;90913008);国家重点基础研究发展计划(2013CB531602);国家科技部科技重大专项(2011ZX09102-002-01);上海市科技重点项目(10431902200)

摘　　要：目的介绍秀丽隐杆线虫(Caenorhabditis clegans)作为模式生物宿主在抗感染研究中的应用,为秀丽隐杆线虫在抗感染研究领域的进一步应用提供参考。方法参阅近年来国内、外相关文献,对其进行分析、整合及归纳。结果发现秀丽隐杆线虫具有生长周期短、成本低等特点,被广泛用于病原微生物致病机制的研究以及抗感染药物的研发。结论秀丽隐杆线虫在病原微生物致病机制研究和抗感染药物研发中有广阔的应用前景。Objective To update the application of Caenorhabditis elegans as a model host of infection in anti-infection re- search field, and provide references for the further application of C. elegans in the research field. Methods The related literatures at home and abroad in recent years were analyzed, integrated and concluded. Results C. elegans had been widely used to study patho- genesis of microorganisms and to screen anti - infective agents, since the nemades had short life cycle and cost low. Conclusion C. elegans would be promising to be further more widely used to study pathogenesis and anti - infective agents.

关 键 词：秀丽隐杆线虫 病原微生物 致病机制 抗感染药物 

分 类 号：R931.74[医药卫生—生药学]