酒石酸唑吡坦的合成  

Synthesis of Zolpidem Tartarate

作　　者：吉锁兴 

机构地区：[1]晋城海斯制药有限公司,山西晋城048006

出　　处：《中国药业》2014年第5期16-17,共2页China Pharmaceuticals

摘　　要：目的 优化酒石酸唑吡坦的合成工艺.方法 以6-甲基-2-（4-甲基苯基）-咪唑并[1,2-α]吡啶为起始原料,通过缩合、还原、甲酯化、胺解、成盐5步反应合成酒石酸唑吡坦.结果 酒石酸唑吡坦总收率由30％ ～ 35％提高到45％左右,副反应少,杂质简单.结论 优化后的合成工艺,操作简单、易行,工艺稳定,可满足工业化生产的要求.Objective To optimize the synthesis process of zolpidem tartrate.Methods With 6-methyl-2-（4-methylphenyl）-imidazo [1,2-αt] pyridine as the starting material,zolpidem tartrate was synthetized by means of five steps condensation,reduction,methyl esterification,ammonolysis and salification.Results The total yieldwas increased from 30%-35% to about 45%,with less side effects and simple impurities.Conclusion The optimized synthesis technology is simple to operate,easy and stable in the process,which can meet the requirements of industrial production.

关 键 词：酒石酸唑吡坦 镇静催眠药 合成 

分 类 号：TQ460.3[化学工程—制药化工] R971.3[医药卫生—药品]