正交试验法优选化癥止痛巴布剂乙醇提取工艺  

Optimization of Ethanol Extraction Technology for Huazheng Analgesic Cataplasm by Orthogonal Design Method

作　　者：罗德祥[1] 梁晓燕[1] 陈丽[1] 雷凯君[1] 李子鸿[1] 

机构地区：[1]广东省佛山市中医院,广东佛山528000

出　　处：《中国药业》2014年第5期40-42,共3页China Pharmaceuticals

摘　　要：目的优选临床中药验方化癥止痛巴布剂的乙醇提取最佳工艺。方法采用L9(34)正交试验法,以丹皮酚的含量和浸膏得率为考察指标,考察乙醇浓度、乙醇用量、回流时间和提取次数对提取率的影响。结果最佳提取工艺为加10倍量的70%乙醇回流提取2次,每次1 h。结论该提取工艺所得丹皮酚和浸膏得率均较高,经验证,稳定、合理可行,适合工业生产。Objective To optimize the optimal ethanol extraction technology for the experiential effective Chinese medicine prescription Huazheng Analgesic Cataplasm.Methods The paeonol content and the extract yield rate were taken as the investigation indexes and the L9（34） orthogonal experiment was adopted to investigate the influence of the ethanol concentration,ethanol amount,reflux time and extraction times on the extraction rate.Results The best extraction technology was adding 10 times the amount of 70% ethanol,decocting twice and 1 h for each time.Conclusion This extraction technology has the high yield rate of paeonol and the extract,which is verified to be stable,rational,feasible and suitable for the industrial production.

关 键 词：正交试验法 化癥止痛巴布剂 丹皮酚 提取工艺 

分 类 号：TQ461[化学工程—制药化工] R286.0[医药卫生—中药学]