山楂消脂胶囊对冠心病患者颈动脉IMT和心脑血管事件发生率的影响  

Effect of Shanzha Xiaozhi Capslue on Intima-media Thickness of Carotid Artery and Cardiovascular and Cerebrovascular Events in Coronary Heart Disease

作　　者：赵华云[1] 王文会[1] 陈伟强[1] 罗子幸[1] 余秀兰[1] 刘照宏[1] 梁彤[1] 

机构地区：[1]广东省佛山市中医院

出　　处：《中西医结合心脑血管病杂志》2014年第2期132-134,共3页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：广东省中医药局基金资助项目(No.20111063)

摘　　要：目的观察山楂消脂胶囊对非急性期冠心病痰瘀证患者颈动脉内-中膜厚度(IMT)和心脑血管事件发生率的影响。方法将符合诊断标准的98例非急性期冠心病痰瘀证患者随机分为两组。对照组48例予基础治疗,治疗组50例加用山楂消脂胶囊,疗程6个月。观察心脑血管事件的发生率,同时,比较治疗前后两组患者颈动脉IMT,并观察两组治疗前后超敏C反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)、低密度脂蛋白胆固醇(LDL-C)的变化。结果治疗组急性心脑血管事件发生率低于对照组(6.00%vs 20.83%,P=0.03),治疗组颈动脉IMT与对照组比较明显降低(P<0.05),同时治疗组可明显降低hs-CRP、Hcy、LDL-C水平,与对照组比较差异有统计学意义(P<0.01)。结论山楂消脂胶囊可能通过降低冠心病患者动脉斑块中的脂质含量,抗炎症反应,减轻颈动脉内中膜的厚度,从而稳定斑块,减少急性心脑血管事件的发生。Objective To investigate the effect of Shanzha Xiaozhi capsule（SXC） on intima - media thickness of carotid artery and major adverse cardiovascular and cerebrovascular events in patients with coronary heart disease and syndrome of phlegm and blood stasis. Methods Ninety - eight patients with coronary heart disease and syndrome of phlegm and blood stasis were randomly divided into two groups：Treatment group （n=50） treated with baseline therapy and SXC, and control group （n=48） treated with baseline therapy. Major adverse cardiovascular and cerebrovascular events two groups were compared. The intima media thickness of carotid artery in two groups was compared. The high - sensitivity C - reactive protein （hs - CRP） ,homocysteine （Hcy） ,and low - density lip- oprotein cholesterol（LDL- C） were measured in both groups before and after the treatment. Results After treatment with SXC,the major adverse cardiovascular and cerebrovascular events in treatment group were reduced significantly compared with that in control group （6.00% vs 20.83% ,P=0.03）. The intimamedia thickness of carotid artery in treatment group was decreased significantly compared with that in control group （P〈0.05）. hs CRP, Hcy,and LDL - C were decreased significantly compared with that in con trol group（P〈0.01）. Conclusion SXC could reduce the lipid,relieve inflammatory reaction,decrease the intima--media thickness of carotid artery, stabilize atherosclerotic plaque and then reduce the major adverse cardiovascular events in coronary heart disease.

关 键 词：冠心病 山楂消脂胶囊 颈动脉内-中膜厚度 心脑血管事件 冠心病 山楂消脂胶囊 颈动脉内-中膜厚度 心脑血管事件 

分 类 号：R259[医药卫生—中西医结合]