卡维地洛对急性心肌梗死病人QT、JT离散度及心率变异性的影响  

Effects of Carvedilol on QT,JT Dispersion and Heart Rate Variability in Acute Myocardial Infarction

作　　者：金道群[1] 刘岑 张凯[1] 陈志强[1] 

机构地区：[1]湖北省黄石市中心医院 [2]湖北省黄石市妇幼保健医院

出　　处：《中西医结合心脑血管病杂志》2014年第2期139-140,共2页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：湖北省黄石市卫生局基金资助项目(No.2012-139)

摘　　要：目的研究卡维地洛对急性心肌梗死病人QT、JT离散度及心率变异性的影响。方法将115例急性心肌梗死病人随机分为卡维地洛组(65例)与对照组(50例),两组均予常规治疗,卡维地洛组加用卡维地洛12.5mg,2次/日,疗程4个月,并随访至半年。检测两组治疗前后QT离散度、JT离散度、心率变异性变化,并记录半年内的不良心血管事件发生情况。结果经过4个月的治疗,两组QT离散度、JT离散度、心率变异性的时域及频域指标较治疗前均明显改善(P<0.01),但卡维地洛组更为明显(P<0.01)。卡维地洛组半年内不良心血管事件发生率较对照组显著减少(P<0.05)。结论卡维地洛可显著减小急性心肌梗死病人QT、JT离散度及提高慢性心率变异性,减少心血管不良事件。Objective To explore the effects of carvedilol on QT,JT dispersion and heart rate variability（HRV） in patients with acute myocardial infarction （AMI）, Methods One hundred and fifteen patients with AMI were randomly divided into the carvedilol group （n=65） and the control group（n= 50）. Each group was given traditional treatment while the carvedilol group was additionly treated with carvedilol for 4 months. The QT,JT dispersion and HRV parameters were detected in both groups before and after treat- ment. All patients were followed up to 6 months. Results After 4 months of treatment,the HRV in the time domain and frequency domain indicators of all patients were improved,so were the QT,JT dispersion. But the effects in carvedilol group was more effective （P（0.01）. Compared to the control group, the incidence of cardiovascular adverse events reduced significantly （P〈0.05）. Conclusion Carvedilol could improve QT,JT dispersion and HRV,which reduced adverse cardiovascuIar events in patients with AMI.

关 键 词：急性心肌梗死 卡维地洛 QT离散度 JT离散度 心率变异性 

分 类 号：R542.22[医药卫生—心血管疾病]