去窦弓神经对大鼠脑细胞线粒体离子泵的影响  

Influence of Sinoaortic Denervation the Ion Pump of Mitochondria of Rats Nerve Cell

作　　者：胡庆[1] 杨丽军[2] 张山起[3] 李淑贞[1] 杨艳梅[1] 顾宇[1] 刘娜[1] 

机构地区：[1]沧州医学高等专科学校生理学教研室 [2]河北省沧州市中心医院 [3]沧州职业技术学院生物化学教研室

出　　处：《中西医结合心脑血管病杂志》2014年第2期227-228,共2页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：河北省沧州市科学技术研究与发展指导计划基金项目(No.1123077ZD)

摘　　要：目的探讨去窦弓神经(SAD)对脑细胞线粒体Na+-K+-ATP酶和Ca2+-ATP酶活性的影响。方法 50只大鼠随机分为对照组、假手术组、SAD 30d组、SAD 60d组、SAD 90d组,分别测定脑细胞线粒体Na+-K+-ATP酶、Ca2+-ATP酶的变化。结果 SAD30d组、SAD60d组、SAD90d组Na+-K+-ATP酶和Ca2+-ATP酶活性明显降低(P<0.01)。结论去窦弓神经使脑细胞线粒体膜的Na+-K+-ATP酶和Ca2+-ATP酶活性明显降低,且随时间延长日益明显。Objective To study the influence of sinoaortic denervation on the enzymatic activity of Na＋ - K＋ - ATP enzyme as well as Ca2＋- ATP enzyme of mitochondria of rats nerve cell. Methods Fifty rats were divided into three groups： Control group,experi- mental group,and sham operation group. The Na＋- K＋- ATP enzyme and Ca2＋- ATP enzyme in mitochondria of the rat nerve cell were determined respectively. Results After operation,the enzymatic activity of Na＋ - K＋ - ATP enzyme as well as Ca2＋- ATP en- zyme was decreased obviously at 30 days, 60 days ,and 90 clays （P〈0.01）. Conclusion Sinoaortic denervation could reduce the ac- tivity of Na＋-K＋- ATP enzyme and Ca2＋- ATP enzyme in mitochondrial membrane of rat nerve cell,and the effect became more evi- dent over time.

关 键 词：去窦弓神经 线粒体 NA+-K+-ATP酶 Ca+-ATP酶 

分 类 号：R965[医药卫生—药理学]