噻托溴铵对重症哮喘患者肺功能及预后的影响  

Effect of tiotropium bromide on pulmonary function and prognosis in patients with severe asthma

作　　者：张添威 毛立群[1] 

机构地区：[1]台州市第一人民医院呼吸内科,浙江台州318020

出　　处：《实用药物与临床》2014年第2期189-192,共4页Practical Pharmacy and Clinical Remedies

摘　　要：目的探讨噻托溴铵对重症哮喘患者肺功能及预后的影响。方法以重症哮喘患者为研究对象,将104例患者随机分为试验组和对照组。试验组给予噻托溴铵粉吸入剂治疗,对照组仅予常规治疗。比较两组治疗前及治疗后6个月肺功能、动脉血气及预后的差别。结果①治疗后,试验组的FEV1%、PEF%和PaO2为77.98%±7.52%、83.2%9±8.26%、(76.51±7.26)mmHg,对照组分别为74.53%±7.33%、79.61%±7.67%、(73.21±7.16)mmHg,试验组均高于对照组,两组比较差异有统计学意义(P<0.05);试验组及对照组的PaCO2分别为(38.68±3.44)mmHg、(41.64±4.09)mmHg,两组比较差异有统计学意义(P<0.05);②试验组的平均住院次数、住院时间、机械通气次数及死亡患者比例分别为(1.10±0.11)次/年、(9.79±0.86)d/年、(0.23±0.04)次/年、8.16%(1/52),对照组分别为(1.22±0.15)次/年、(10.41±0.95)d/年、(0.26±0.06)次/年、25.00%(7/52),两组比较差异有统计学意义(P<0.05);③试验组总不良反应发生率(30.95%)与对照组(19.05%)比较,差异无统计学意义(P=1.492,χ2=0.222)。结论噻托溴铵可改善重症哮喘患者肺功能和预后,且不增加药物不良反应。Objective To explore the effect of tiotropium bromide on pulmonary function and prognosis in patients with severe asthma. Methods The patients were divided into observation group（ accepted the treatment of tiotropium bromide）and control group （received conventional therapy ）randomly, The difference of FEV1% , PEF% , PaO2 and PaCOz were compared between the two groups. Results ①The FEV1%, PEF% and PaO2 in observation group [77.98% ±7.52% ,83.29% ±8.26% , （76. 51 ±7.26）mmHg] were significantly higher than those of control group [74.53% ±7.33% ,79. 61% ±7.67% , （73.21 ±7. 16） mmHg] ,and the PaCO2 in observation group was significantly higher than that of control group [ （38. 68 ± 3.44）mmHg vs. （41.64 ± 4. 09 ）mmHg ] after 6 months of treatment （P 〈 0.05 ）. ②The frequency of hospitalization, time of hospitalization, frequency of mechanical ventilation and mortality rate in observation group [ （ 1. 10 ± 0. 11 ） times per year, （9. 79 ± 0. 86） d per year, （0. 23 ± 0. 04） times per year, 8. 16% （1/52） ] were significantly lower than those in control group[ （ 1.22 ± 0. 15 ） times per year, （ 10. 41 ± 0. 95 ） d per year, （0. 26 ± 0. 06 ） times per year, 25.00% （7/52） ], there were significant differences between the two groups （ P 〈 0.05 ）. ③There＇s no significant difference of adverse drug reaction between the observation group（ 30. 95 % ） and the control group （ 19.05 % ） （ P 〈 0. 05 ）. Conclusion Tiotropium bromide could improve pulmonary function and prognosis in patients with severe asthma.

关 键 词：噻托溴铵 重症哮喘 肺功能 预后 

分 类 号：R562.25[医药卫生—呼吸系统]