晚期血吸虫病肝纤维化程度与生化指标的相关性  

Correlation between levels of liver fibrosis and liver fibrosis biochemical parameters of advanced schistosomiasis patients

作　　者：吴一鸣[1] 徐晓菲[1] 乌文琳[1] 邬万新[1] 高树兴[1] 朱文军[1] 

机构地区：[1]浙江省嘉兴市第一医院,嘉兴314000

出　　处：《中国血吸虫病防治杂志》2014年第1期65-66,77,共3页Chinese Journal of Schistosomiasis Control

摘　　要：目的探讨晚期血吸虫病肝纤维化程度与肝纤维化生化指标之间的相关性。方法以48例晚期血吸虫病肝病患者为研究对象,行肝活检及B超影像学检查,同时检测谷氨酰胺转肽酶(GGT)、碱性磷酸酶(AKP)、Ⅲ型前胶原(PC-Ⅲ)、Ⅳ型胶原(Ⅳ-C)、透明质酸(HA)及层粘连蛋白(LN)等肝纤维化生化指标。分别以肝活检病理结果和B超影像学检查确定肝纤维化程度,分析肝纤维化程度与上述肝纤维化生化指标间的相关性。结果肝活检病理检查确定的肝纤维化程度与各生化指标之间无相关性;B超影像学检查确定的肝纤维化程度与GGT、AKP、LN和PC-Ⅲ之间有一定相关性,与HA和Ⅳ-C呈显著相关。结论 B超检查是一种较好的无创性血吸虫病肝纤维化检查方法,结合肝纤维化生化指标能更好地反映肝脏整体状况。Objective To explore the correlation between the levels of liver fibrosis and liver fibrosis biochemical parameters of advanced schistosomiasis patients. Methods A total of 48 advanced schistosomiasis patients were investigated and they were examined by the liver biopsy and B ultrasound imaging. At the same time, the liver fibrosis biochemical parameters, including glu tamine transpeptidase （GGT）, alkaline phosphatase （AKP）, procollagen Ⅲ （PC-Ⅲ）, collagen type Ⅳ （Ⅳ-C）, hyaluronic acid （HA） and laminin （LN）, were detected. The liver fibrosis levels were classified by the liver biopsy and B ultrasound imaging, re spectively, and the correlation between the levels of liver fibrosis and liver fibrosis biochemical parameters were analyzed statisti cally. Results There was no correlation between the liver fibrosis levels classified by the liver biopsy and all the liver fibrosis bio chemical parameters; there was a weak correlation between the liver fibrosis levels classified by the B ultrasound imaging and GGT, AKP, LN and Pc-Ⅲ, respectively; there was a significant correlation between the liver fibrosis levels classified by the B ul trasound imaging and HA and IV-C, respectively. Conclusions B ultrasound examination is a better, noninvasive fibrosis in spection method. Liver fibrosis biochemical parameters combined with the B ultrasound examination may better reflect the overall condition of liver fibrosis.

关 键 词：晚期血吸虫病 肝纤维化 B超 肝活检 相关性 

分 类 号：R532.21[医药卫生—内科学]