气道炎症性亚急性咳嗽应用三拗片治疗的效果观察  

Clinical effect of San＇ao Pian on treating subacute cough induced by airway inflammation

作　　者：张洁[1] 唐瑾[2] 厉旭光[3] 何翔[4] 张路[4] 尹琦[4] 郭忠良[1] 

机构地区：[1]同济大学附属东方医院特诊部,上海200120 [2]同济大学附属东方医院急诊医学部,上海200120 [3]宁波大学医学院附属医院重症医学科 [4]同济大学附属东方医院呼吸内科,上海200120

出　　处：《中国综合临床》2014年第2期183-186,共4页Clinical Medicine of China

摘　　要：目的 探讨气道炎症性亚急性咳嗽应用三拗片干预的疗效及安全性.方法 选取我院诊治的90例无影像学异常的亚急性咳嗽患者,随机分为两组,治疗组（45例）在常规治疗基础上加用三拗片,1.0g/次口服,3次/d;对照组（45例）仅给予常规治疗,连续治疗2周.观察患者治疗第3、7、14天临床症状的变化.结果 （1）呼吸道症状评分：两组咳嗽症状积分较治疗前均有所改善（P均＜0.01）,其中以治疗组明显.组间分析发现,治疗组在第3、7、14天日间咳嗽症状评分[（2.18±0.62）、（1.22±0.46）、（0.83 ±0.45）分]、夜间咳嗽症状评分[（2.12±0.51）、（1.18±0.44）、（1.01 ±0.32）分]均显著低于对照组[日间咳嗽症状评分（2.78 ±0.55）、（2.05±0.41）、（1.86±0.68）分,夜间咳嗽症状评分（2.38 ±0.38）、（1.85 ±0.49）、（1.24±0.37）分],差异均有统计学意义（F组内=10.23,P＜0.05;F组间=8.46,P ＜0.05;F交互=12.05,P＜0.05;F组内=6.38,P＜0.05;F组间=7.59,P＜0.05;F交互 =8.13,P均＜0.05）.（2）总体疗效：治疗组22例痊愈,17例显效,总有效率86.7％;对照组痊愈14例,显效17例,总有效率68.9％;治疗组总有效率显著高于对照组（x2 =9.172,P＜0.01）.（3）两组均未发现明显不良反应.结论 三拗片对于气道炎症性亚急性咳嗽患者的呼吸道症状改善作用较好,且安全性高,值得临床推广应用.Objective To investigate the clinical effect and safety of San＇ ao Pian＇s treatment on subacute cough induced by airway inflammation.Methods Ninety cases with subacute cough induced by airway inflammation were selected as our subjects.They were randomly divided into control group（n =45） and San＇ao Pian group（n =45）.Patients in control group were given regular treatment,and in San＇ao Pian group were received San＇ao Pian＇s（1.0 g/time oral,3 times/day） for 2 weeks plus regular treatment.The changes of clinical symptoms such as cough,sputum,and wheeze were observed and recorded at the 3th,7th,14th day.Results （1） The main symptoms regarding of cough were improved in two groups（P ＜ 0.01）.The day cough symptoms score in San＇ao Pian group were （2.18 ±0.62）,（1.22 ±0.46）,（0.83 ±0.45） at the 3th,7th,14th days after treatment,lower than that of control group （（2.78 ± 0.55）,（2.05 ± 0.41）,（1.86 ± 0.68）） and the differences were significant（F within group =10.23,P ＜ 0.05 ; F between =8.46,P ＜ 0.05 ; F intercross group =12.05,P ＜ 0.05）.The same trend was seen in night cough symptoms score （（2.12 ± 0.51） vs.（2.38 ±0.38）,（1.18±0.44） vs.（1.85±0.49）,（1.01 ±0.32） vs.（1.24±0.37） ;Fwithingroup=6.38,P ＜ 0.05 ; F between group =7.59,P ＜ 0.05 ; F intercross group =8.13,P ＜ 0.05）.（2） The total efficacy rate of San＇ao Pian＇s was 86.7％,including 22 cases were cured,17 cases markedly effective,higher than that of control group （68.9％）,including 14 cases were cured and 17 cases markedly effective,and the difference was significant.Conclusion San＇ao Pian＇s is proved with better clinical effect in terms of treating subacute cough induced by airway inflammation.

关 键 词：亚急性咳嗽 三拗片 中药治疗 

分 类 号：R56[医药卫生—呼吸系统]