早期服用曲美他嗪对PCI围手术期心肌的保护作用  

Protective effect of early using Trimetazidine on myocardial injury following percutaneous coronary intervention

作　　者：张峰[1] 陈欣[1] 张淑翼 

机构地区：[1]天津市第一中心医院心内科,天津1300192 [2]天津医科大学一中心临床学院,天津300070

出　　处：《新医学》2014年第1期38-41,共4页Journal of New Medicine

摘　　要：目的探讨不稳定型心绞痛患者行PCI介入治疗前早期(3个月)应用曲美他嗪对PCI围手术期心肌的保护作用。方法 150例不稳定型心绞痛患者随机分为曲美他嗪组和对照组。曲美他嗪组在常规药物基础上,于术前3个月开始口服曲美他嗪(20 mg,tid)。两组均于术前、术后1 h、术后1 d记录同步12导联心电图;于PCI术前、术后6、12、24、48 h测定患者心肌肌钙蛋白I(cTnI)水平。结果最终纳入82例成功行PCI手术的不稳定型心绞痛患者(曲美他嗪组42例,对照组40例)。PCI术后曲美他嗪组cTnI水平低于对照组,差异有统计学意义(P<0.05);与对照组相比,曲美他嗪组PCI相关心肌梗死的发生率较低(5%vs 15%,P=0.028)。结论 PCI术前早期(3个月)服用曲美他嗪可以减少围手术期心肌损伤,降低PCI相关心肌梗死的发生率。Objective To explore the protective effect of early using Trimetazidine （TMZ）before percutaneous coronary intervention （PCI）on the unstable angina patients. Methods One hundred and fifty unstable angina patients were randomly divided to control group and trimetazidine treatment group. Patient in trimetazidine treatment group must take trmetazidine （20 mg,tid）for 3 months before PCI. 1 2-lead ECG was recorded before,1 h after PCI and the following day. The cardiac troponin I （cTnI）level were measured be-fore and 6、1 2、24、48 h after PCI. Results Totally 82 patients who successful undergo elective？PCI were finally enrolled,42 were assigned into TMZ group and 40 into control group. Compare to control group,the cT-nI level were significantly reduced in the TMZ group （P〈0.05 ）. The incidence of PCI-related myocardial in-farction （PMI）was significantly decreased in TMZ group （5%vs 1 5%,P=0.028）. Conclusion Early u-sing TMZ before PCI on the unstable angina patients can decrease the damage to myocardium and reduce the in-cidence of PMI.

关 键 词：经皮冠状动脉介入治疗 曲美他嗪 经皮冠状动脉介入相关心肌梗死 

分 类 号：R542.22[医药卫生—心血管疾病]