血三七胶囊制剂成型工艺的优选研究  

Study on optimization of preparation process about Xuesanqi capsules

作　　者：苏汉文[1] 林慧芳[2] 向梅先[2] 

机构地区：[1]武汉大学人民医院,武汉430063 [2]中南民族大学药学院,武汉430074

出　　处：《华中师范大学学报（自然科学版）》2014年第1期62-65,共4页Journal of Central China Normal University：Natural Sciences

基　　金：国家自然科学基金项目(31200264);武汉市科技攻关项目(201260523189)

摘　　要：采用比较试验法优选出血三七胶囊制剂的成型工艺.采用单因素比较试验,考察了辅料的种类及用量,颗粒的临界相对湿度等以确定最佳的提取工艺.结果优选的成型工艺为:浸膏粉∶淀粉∶糊精=20∶8∶14.4时,乙醇浓度为85%;干燥温度50℃,硬脂酸镁用量超过干燥颗粒总量的0.8%,颗粒的临界相对湿度约为67%时,颗粒的稳定性和流动性较好.在上述条件下,胶囊填充性较好、贮存稳定.To optimist preparation process of Xuesanqi capsules,which provide the basis for follow-up study by comparative test.Single factor comparison test was used to investigate the type and amount of excipients,the critical relative humidity of particles,etc,in order to determine the optimum extraction process.The optimal moulding process was as follow：the powder of extract ∶ starch ∶ dextrin=20 ∶ 8 ∶ 14.4,the concentration of ethanol was 85％,the drying temperature was 50℃,the dosage of magnesium stearate was more than 0.8％ of the total of drying granules,the critical relative humidity was about 67 ％,the stability and liquidity of particles were good in the above conditions.The capsules were filled well and storaged stability.

关 键 词：血三七胶囊 制剂成型工艺 比较试验 

分 类 号：R282.7[医药卫生—中药学]