成年男性同型半胱氨酸与性激素水平的相关性研究  

Relationship of serum homocysteine with sex hormone in males

作　　者：施德毅 梁振家 黄章 陈永东 莫曾南[2,3] 张幼捷 谢远亮[2] 谭爱花[3] 高勇[3] 严芝光 

机构地区：[1]防城港市第一人民医院心血管内科,广西防城港538000 [2]广西医科大学第一附属医院泌尿外科,广西南宁530021 [3]广西医科大学基因组与个体化医学研究中心,广西南宁530021 [4]防城港市第一人民医院检验科,广西防城港538000

出　　处：《海南医学》2014年第3期323-326,共4页Hainan Medical Journal

基　　金：广西自然科学基金项目资助(编号:2010GXNSFA013133)

摘　　要：目的探讨成年男性血清同型半胱氨酸(Hcy)与性激素水平的关系。方法对2009年9～12月在防城港市第一人民医院体检中心进行健康体检的1 922名成年男性进行横断面调查。分别采用电化学发光免疫法、循环酶法测定血清性激素与Hcy水平。以多元线性回归分析Hcy与各性激素水平的相关关系。结果年龄、卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)及内生肌酐清除率(Ccr)在不同Hcy水平组中分布差异存在统计学意义(P值分别为0.001、0.001、0.002、0.007及0.001)。在多元线性回归模型中,校正年龄、BMI、Ccr、吸烟、饮酒及体力活动后,血清Hcy与E2呈正相关性(β=0.083,95%CI:0.039～0.127),而与FSH、LH、T及SHBG无相关性。结论在健康成年男性中,空腹血清Hcy水平与E2独立相关。Objective To explore the relationship between serum homocysteine （Hey） and sex hormone in adult males. Methods A total of 1 922 men aged 20 to 69 years who participated in the population-based Fangcheng- gang Area Male Health and Examination Survey （FAMHES）, which was carded out in Guangxi province of China from September 2009 to December 2009, were assessed in this cross-section study. Serum sex hormone was measured with electrochemiluminescence immunoassay. Multiple linear regression analysis was performed to analyze the associ- ations between Hcy and sex hormones. Results Factors as age, the levels of follicle-stimulating hormone （FSH）, lu- teinizing hormone （LH）, estradiol （E2） and endogenous creatinine clearance rate （Ccr） differed significantly in four groups of different Hey levels （P=0.001, P=0.001, P=0.002, P=-0.007 and P=0.001, respectively）. In multiple linear re- gression models, after adjustment for age, BMI, Ccr, smoking, drinking, and physical activity, serum Hcy had posi- tive correlation with E2 （β=0.083, 95%CI： 0.039-0.127）, but had no relationships with FSH, LH, T, and SHBG. Conclusion In healthy males in Fangchenggang, E2 levels are independently associated with the Hcy levels.

关 键 词：男性 同型半胱氨酸 性激素 

分 类 号：R446.6[医药卫生—诊断学]