促甲状腺激素、甲状腺球蛋白浓度在甲状腺良、恶性结节诊断中的价值  

Diagnostic Value of Serum Thyroid Stimulating Hormone and Thyro globulin Levels in Differentiating Thyroid Benign and Malignant Nodules

作　　者：吕坤祥[1] 宋智明[1] 朱利国[1] 孙志强[1] 何拥军[1] 

机构地区：[1]江苏省原子医学研究所,卫生部核医学重点实验室,江苏省分子核医学重点实验室,江苏省江原医院

出　　处：《标记免疫分析与临床》2014年第1期74-76,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：目的探讨血清促甲状腺激素(TSH)、甲状腺球蛋白(Tg)浓度变化在甲状腺良、恶性结节诊断中临床价值。方法选取96例因甲状腺结节病住院患者,比较甲状腺良、恶性结节患者血清TSH、Tg浓度差异,分析血清TSH、Tg浓度与甲状腺良、恶性结节的关系。结果甲状腺恶性结节组血清TSH浓度(2.55±1.46mIU/L)与甲状腺良性结节组(1.15±1.10mIU/L)比较,差异有统计学意义(P<0.05);随血清TSH浓度的升高,甲状腺恶变结节比例升高;甲状腺恶性结节组血清Tg浓度(255.0±60.6ng/mL)高于甲状腺良性结节组(115.0±32.4ng/mL)(P<0.05),不同血清Tg浓度组间甲状腺恶性结节数比例差异无统计学意义(P>0.05)。结论血清TSH、Tg浓度检测对甲状腺良、恶性结节诊断中有一定临床意义,血清TSH浓度是预测甲状腺结节恶变的危险因子。Objective To explore the changes of serum thyroid stimulating hormone （TSH） and thyroglobulin （Tg） levels and their clinical value in the diagnosis of differentiating thyroid malignant and benign nodules. Methods The serum levels of TSH and Tg in 96 patients with thyroid nodular disease were measured, the relationship between the serum TSH andTg levels of patients with benign and malignant thyroid nodules were analyzed. Results The serum TSH levels in patients with thyroid carcinoma and with benign thyroid nodules were 2.55 ±1.46 mlU/L and 1.15 ± 1.10 mIU/L respectively and had significantly different （P 〈 0.05）. The ratio of thyroid nodule canceration was increase as the increase of serum levels of TSH in patients with thyroid nodular disease. The serum Tg levels in thyroid cancer patients were significantly higher than that in patients with benign thyroid nodules （ P 〈 0.05 ）. There was no significantly difference in the malignant thyroid nodule numbers between different serum Tg levels （ P 〉 0.05 ）. Conclusion The detection of serum TSH and Tg has certain clinical significance in the diagnosis of malignant and benign thyroid nodule, and serum TSH level might be used as a factor in prediction of thyroid nodule canceration.

关 键 词：促甲状腺激素 甲状腺球蛋白 甲状腺良性结节 甲状腺恶性结节 甲状腺肿 临床诊断 

分 类 号：R581[医药卫生—内分泌] R736.1[医药卫生—内科学]