醋酸乌利司他假多晶型分子热分解机理及动力学  

Molecular Thermal Decomposition Mechanism and Kinetics of Ulipristal Acetate Pseudo-polymorph

作　　者：雷绒绒 朱亮[1] 沙作良[1] 王彦飞[1] 王海 

机构地区：[1]天津市海洋资源与化学重点实验室,天津科技大学海洋科学与工程学院,天津300457 [2]华润紫竹药业有限公司,北京100024

出　　处：《天津科技大学学报》2014年第1期25-29,共5页Journal of Tianjin University of Science & Technology

基　　金：国家自然科学基金资助项目(21076157);高等学校博士学科点专项科研基金资助项目(20121208120001)

摘　　要：通过冷却结晶实验制备醋酸乌利司他以乙醇为溶剂的假多晶型晶体.热重实验结果表明醋酸乌利司他假多晶型在升温过程中包含溶剂脱除与分子热分解2个过程.利用非等温热重法对醋酸乌利司他假多晶型的分子热分解过程机理及其动力学进行研究.基于不同热分解机理所对应的反应动力学机理函数,结合醋酸乌利司他假多晶型非等温热分解实验数据,计算估测醋酸乌利司他假多晶型分子热分解的机理,并计算得到这一过程所对应的热分解动力学方程.Ulipristal acetate pseudo-polymorph was prepared by cooling crystallization in ethanol.According to TG data,the thermal decomposition of ulipristal acetate pseudo-polymorph included two processes which were desolvation and molecular thermal decomposition as the temperature increased. Non-isothermal thermogravimetry was applied to study the thermal decomposition mechanism and thermal decomposition kinetics of molecular thermal decomposition of ulipristal acetate pseudo-polymorph. Based on different kinetic functions of corresponding molecular thermal decomposition mechanisms and the experimental data of ulipristal acetate pseudo-polymorph,the decomposition mechanism of molecular thermal decompo-sition process was analyzed and estimated,and the corresponding kinetic equation was also obtained.

关 键 词：醋酸乌利司他 假多晶型 非等温热重法 热分解动力学 热分解机理 

分 类 号：R979.21[医药卫生—药品]