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作 者:梁国庆[1] 于晓华[2] 吴旻[3] 沈育忠 李建辉[2] 郑俊彪 王峻[2] 李余敏[2] 俞金峰 李冬[2] 李铮[3]
机构地区:[1]上海中医药大学附属市中医医院泌尿外科,上海200071 [2]浙江省嘉善县第一人民医院泌尿外科,嘉善314100 [3]上海交通大学医学院附属仁济医院泌尿外科,上海200135
出 处:《上海交通大学学报(医学版)》2014年第2期169-172,共4页Journal of Shanghai Jiao tong University:Medical Science
基 金:上海市卫生局课题(20134392);上海市科委重大科研基金(09DJ1400400)~~
摘 要:目的探讨中老年男性勃起功能(EF)与血清总睾酮(TT)、游离睾酮(FT)和生物活性睾酮(Bio-T)之间的相关关系。方法采用问卷调查的方式,比较236例正常勃起人群,369例轻度勃起功能障碍(ED)和390例中、重度ED患者的勃起功能指数评分(IIEF),化学发光法(CLIA)检测TT和性激素结合球蛋白(SHBG),计算FT和Bio-T水平。结果中老年男性人群的ED发病率为76.28%,随着增龄而显著升高。ED患者的TT水平略低于正常勃起人群,但差异无统计学意义(P>0.05);而FT和Bio-T显著低于正常勃起人群,差异具有统计学意义(P<0.01)。TT在不同IIEF评分的ED患者之间没有变化规律,FT和Bio-T则随着IIEF评分的减低而明显下降。Pearson相关分析显示:TT与IIEF评分之间无相关性,FT和Bio-T与IIEF评分呈显著正相关(P<0.01)。结论中老年男性ED发病率随增龄显著升高。TT水平与ED无明显相关关系,而FT和Bio-T与ED显著相关;FT和Bio-T内分泌诊断价值优于TT,更能准确反应ED患者的血清睾酮水平。Objective To study the relationship of erectile function (EF) and serum total testosterone (TT), free testosterone (FT), and bioavailable testosterone (Bio-T) of old and middle-aged males. Methods The International Index of Erectile Function questionnaires was used to evaluate 236 people with normal EF, 369 patients with mild erectile dysfunction (ED), and 390 patients with moderate and severe ED. The serum total testosterone (TT) and sex hormone- binding globulin (SHBG) were measured by chemilum inescentenzyme immunoassay (CLIA) method, and free testosterone (FT) and bioavailable testosterone (Bio-T) levels were calculated. Results The incidence of ED was 76.28% among old and middle-aged males and increased significantly with the age. The TT levels of ED patients were slightly lower than those of people with normal EF (P 〉 O. 05). While FT and Bio-T values were significantly lower than those of people with normal EF (P 〈0.01). The variations of TT among ED patients with different IIEF scores are not regular, while FT and Bio-T decreased significantly with decreasing of IIEF score. Pearson regression analysis revealed that TT was not related to IIEF score, while FT and Bio-T were significantly related to IIEF score ( P 〈 0.01). Conclusion The incidence of ED among old and middle-aged males increases significantly with the age. The TT level is not significantly related to ED, but FTand Bio-T are significantly related to ED. The endocrine diagnostic value of FT and Bio-T is better than TT and can reflect the serum testosterone level of ED patients more accurately.
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