左西孟旦治疗急性失代偿性心力衰竭的效果评价  

Evaluation of clinical efficacy of levosimendan in acute decompensated heart failure

作　　者：吴秀绍 邢钰[1] 闫西艴[1] 张彦周[1] 

机构地区：[1]郑州大学第一附属医院心血管内科,河南郑州450052

出　　处：《河南医学研究》2014年第1期31-33,共3页Henan Medical Research

摘　　要：目的：评价左西孟旦治疗急性失代偿性心力衰竭的临床效果.方法：将60例常规治疗不能缓解的急性失代偿性心力衰竭患者随机分为两组.研究组给予左西孟旦治疗,以0.1 p.g/（kg· min）持续输注24 h;对照组给予多巴酚丁胺5 ～ 10 μg/（kg·min）持续输注24 h.治疗前后评估患者全身状况、生命体征并检测24 h尿量、脑钠肽（BNP）、左室射血分数（LVEF）、每搏输出量（SV）等相关指标的变化.结果：与对照组相比,研究组在改善全身状况、增加24 h尿量、降低BNP、改善LVEF、增加SV方面均表现显著优势（P＜0.05）.结论：左西孟旦对于急性左心衰患者疗效优于多巴酚丁胺,能明显改善患者心功能及心力衰竭症状.Objective： To evaluate the efficacy of levosimendan in acute decompensated heart failure. Methods： 60 patients with acute decompensated heart failure that could not be alleviated with conventional treatment were randomized into 2 groups. The control group was given dobutamine, and the experimental group was treated with levosimendan. BNP, 24 hourly urine volume, LVEF and SV were detected and the systemic clinical conditions were assessed both before and after the treatment. Results： The extent of improvement of systemic symptoms and relevant indicators such as BNP, 24 hourly urine, LVEF and SV in experimental group was larger than that in control group （P 〈 0.05）. Conclusion ： Levosimendan was superior to dobutamine for patients with acute decompensated heart failure,which improved the with acute decompensated heart failure. cardiac function and relieve symptoms of patients

关 键 词：左西孟旦 急性失代偿性心力衰竭 心功能 

分 类 号：R541.6[医药卫生—心血管疾病]