依那普利联合硝苯地平控释片治疗原发性高血压的疗效观察  

作　　者：苗保霞 刘同宝[1] 

机构地区：[1]山东大学附属省立医院心血管内科,250021 [2]山东省淄博市沂源县人民医院心血管内科,256100

出　　处：《中国医疗前沿》2013年第23期36-36,114,共2页China Healthcare Innovation

摘　　要：目的观察依那普利联合硝苯地平控释片治疗原发性高血压的临床疗效及安全性。方法按照随机、双盲、对照原则将120例原发性高血压患者分为A、B、C三组,分别给予依那普利、硝苯地平缓释片及两种药物联合应用治疗,对比三组降压效果及不良反应。结果治疗4周后,A、B组总有效率均显著低于C组(P<0.05);C组SBP和DBP值均明显低于同期A组、B组(P<0.05)。三组患者不良反应均较轻,组间差异无统计学意义(P>0.05)。结论依那普利联合硝苯地平控释片对原发性高血压患者的降压效果明显,不良反应较轻,与单独用药相当,值得推广应用。Objective To observe the clinical efficacy and safety of enalapril and nifedipine on treatment of essential hypertension. Method According to a randomized, double-blind, controlled principle, 120 patients with essential hypertension were divided into A, B, C groups, patients in each group were given enalapril, nifedipine, and the two drugs in combination therapy individually, the antihypertensive effect and adverse reactions of the three groups were compared and analyzed. Results After 4 weeks treatment, the total effective rate of group A and B were significantly lower than that of group C（P〈0.05） ; SBP and DBP values of group C were significantly lower than that of group A, group B of the same period, the difference were significant（P〈0.05）. Adverse reactions were mild in all patients, there was no statistical significance among the three groups（P〉0.05）. Conclusion Enalapril and nifedipine is effective in treating patients with essential hypertension antihypertensive with less adverse reactions, which is quite worthy of popularization and application.

关 键 词：原发性高血压 依那普利 硝苯地平缓释片 联合用药 

分 类 号：R544.1[医药卫生—心血管疾病]