马来酸桂哌齐特与氯化钾注射液在氯化钠注射液中配伍稳定性考察  

Study of compatible stability of maleate cinepazide and potassium chloride injection in sodium chloride injection

作　　者：王群[1] 谢冬梅[1] 王娟[1] 郭道华[1] 

机构地区：[1]蚌埠医学院第一附属医院药剂科,安徽省蚌埠市233004

出　　处：《临床合理用药杂志》2014年第7期40-42,共3页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的 考察马来酸桂哌齐特在25℃和37℃时与氯化钾注射液在氯化钠注射液中的配伍稳定性.方法 将马来酸桂哌齐特与氯化钾注射液加入氯化钠注射液中,混合均匀后,在25℃和37℃于0,1,2,4,6h时采用紫外分光光度法,测定马来酸桂哌齐特含量,同时记录外观变化和pH值.结果 0～6h内混合液外观基本无变化,pH值基本稳定,马来酸桂哌齐特的含量无明显变化.结论 在25℃和37℃避光条件下,马来酸桂哌齐特与氯化钾注射液在氯化钠注射液中可配伍使用,宜在6h内用完.Objective To investigate the compatible stability of maleate cinepazide and potassium chloride injection in sodium chloride injection in 25℃ and 37℃. Methods The samples of the complexes were collected at the 0, lst,2nd,gth, and 6th hour after rmixing cinepazide maleate injection and potassium chloride injection in sodium chloride injection at the temperature of 25℃ and 37℃, the contents and the changes of ultraviolet absorptions pectrum of cinepazide maleate injection and potassium chloride injection were determined by UV-spectrophotometry. The pH value were detected and the external ap- pearance, color, diaphamneity of the mixtures were observed. Results There were no visible changes within 6 hours in terms of the appearance, pH ,forms of peaks of the complexes. No significant content changes of cinepazide maleate were found under the experiment condition. Conclusion Cinepazide maleate injection and potassium chloride injection in sodium chloride injection mixed under the room temperature are compatible and can be used within 6 hours.

关 键 词：马来酸桂哌齐特 氯化钾注射液 氯化钠注射液 稳定性 紫外分光光度法 

分 类 号：R969.3[医药卫生—药理学]