DNA甲基转移酶1基因多态与噪声性听力损失易感性  

Association between SNPs in DNMT1 and noise-induced hearing loss in Chinese Han population

作　　者：胡飞飞[1] 张恒东[2] 李昕[3] 卞倩[2] 朱宝立[2] 张正东[4] 

机构地区：[1]常州市疾病预防控制中心,常州213022 [2]江苏省疾病预防控制中心 [3]南京市疾病预防控制中心 [4]南京医科大学公共卫生学院

出　　处：《中华劳动卫生职业病杂志》2014年第2期104-107,共4页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：江苏省自然科学基金资助项目（BK2010575）;江苏省医学创新团队与领军人才项目（LJ201130）

摘　　要：目的 探讨DNA甲基转移酶1基因（DNMT1） rs12984523、rs16999593和rs2228612单核苷酸多态性与中国汉族人群中噪声性听力损失（NIHL）易感性之间的关联.方法 采用病例-对照研究,电测听双耳高频平均听阈值≥40 dB为病例组,共188名工人；电测听结果双耳高频平均听阈值＜40dB的300名工人为对照组.应用TaqMan探针法检测3个SNP位点的基因型.结果 DNMT1rs2228612携带TT基因型为NIHL的危险因素（调整后OR=1.69,95％CI：1.14～2.52）.结论 在188例电测听双耳高频平均听阈值≥40 dB的中国汉族人群中,DNMT1 rs 2228612与噪声性听力损失的易感性有关.Objective To investigate the association between single nucleotide polymorphisms （SNPs） in DNA methyltransferase 1 （DNMT1） （rs12984523,rs16999593,and rs2228612） and noise-induced hearing loss （NIHL） in Chinese Han population.Methods This case-control study consisted of 188 cases （case group） and 300 controls （control group） in the same working position,who were matched for age and gender.The cases had a binaural average high-frequency hearing threshold not less than 40 dB,and the controls had a binaural average high-frequency heating threshold less than 40 dB.The genotypes at the three SNPs were determined by TaqMan probe.Results TT genotype at DNMT1 rs2228612 is a risk factor for NIHL （adjusted OR=1.69,95％ CI：1.14-2.52）.Conclusion The study of Chinese Han population suggested that DNMT1 rs2228612 is associated with susceptibility to NIHL.

关 键 词：DNA甲基转移酶1 职业性听力损失 噪声 

分 类 号：R135.8[医药卫生—劳动卫生]