活动性结核病人血清sTNFR-Ⅰ变化的临床研究  

Clinical Investigation of Soluble Tumor Necrosis Factor Receptor-Ⅰ in Serum of Patients with Acute Tuberculosis

作　　者：刘劲[1] 李丽云[1] 

机构地区：[1]中国医科大学第一临床学院感染科,沈阳110001

出　　处：《中国医科大学学报》2001年第1期36-37,共2页Journal of China Medical University

摘　　要：目的 :探讨活动性结核患者血清可溶性 TNF受体 - (s TNFR- )水平的变化。方法 :用双抗体夹心EL ISA法检测血清 s TNFR- 水平。结果 :活动性结核 ,特别是播散性结核患者血清 s TNFR- 水平较正常对照组明显增高 (P <0 .0 1) ;随诊观察抗结核治疗后 ,患者血清 s TNFR- 水平有不同程度下降。结论 :监测血清 s TNFR-Objective: Our purpose was to study the concentration of soluble tumor necrosis factor receptor Ⅰ(sTNFR Ⅰ) in the serum of patients with acute tuberculosis. Methods: The levels of soluble TNFR Ⅰ in serum were measured in 11 patients with acute tuberculosis. Concentration of sTNFR Ⅰ were measured by using enzyme linked immunological binding assay. Results: In patients with acute tuberculosis, especially severe tuberculosis, serum levels of sTNFR Ⅰ increased significantly (P<0.01), compared with those of control. After antituberculosis therapy, serum levels of sTNFR Ⅰin patients with acute tuberculosis decreased by various degrees. Conclusion: Measurements of sTNFR Ⅰ in serum of patients with acute tuberculosis could be an important index in the judgement of the outcome of the disease.

关 键 词：活动性结核病 血清 STNFR-I ELISA 临床研究 

分 类 号：R52[医药卫生—内科学]