加味逍遥丸调节围绝经期情绪障碍的疗效对比评价  

Comparison of Jiawei Xiaoyao Pills in treating women with emotional disorder during perimenopause

作　　者：王文慧 岳利峰[2] 杜茂生 高英英 王琦[5] 奚胜艳[6] 

机构地区：[1]山西省忻州市岢岚县岚漪镇计生办,忻州036300 [2]北京中医药大学东直门医院,北京100700 [3]岢岚县人民医院,忻州036300 [4]岢岚县中医院,忻州036300 [5]北京工商大学,北京102401 [6]厦门大学医学院,厦门361005

出　　处：《中华中医药杂志》2014年第3期836-839,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学青年基金项目(No.81302960)~~

摘　　要：目的:探讨加味逍遥丸治疗围绝经期情绪障碍的优势。方法:经筛选后具有抑郁或焦虑的围绝经期女性患者80例随机等分为帕罗西汀组、利维爱组、帕+利组和加味逍遥丸组,分别给予相应药物治疗8周。所有患者在治疗前后均进行1次围绝经期症状主诉量表(Greene)、汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)评定,并在观察期结束时进行副反应量表(TESS)评定。结果:Greene、HAMA评分:4种治疗方法均能改善,且相互间无统计学差异;HAMD评分:除利维爱组均有效改善(P<0.01),帕+利组和加味逍遥丸组优于帕罗西汀组(P<0.05),且帕+利组和加味逍遥丸组间无统计学意义;TESS评分:前3组与加味逍遥丸组比较均有统计学意义(P<0.01),评分均大于加味逍遥丸组,且前3组间无统计学差异。结论:考虑到帕罗西汀的毒副作用和利维爱潜在的、远期的危险性,治疗该病加味逍遥丸值得推荐。Objective： To explore the superiority of Jiawei Xiaoyao Pills in treating perimenopausal women with emotional disorder. Methods： 80 perimenopausal women with emotional disorder screened by SAS and SDS were randomly divided into 4 equal groups： Paroxetine group, Livial group, Paroxetine combined with Livial group, Jiawei Xiaoyao Pills group, 20 in each group. All of them accepted 8 weeks＇ therapy. Every patient accepted the assessment of these rating scales （including Greene, HAMA, HAMD） one time before and after treatment, and only one test for TESS after treatment. Results： All regimens improved the score of Greene and HAMA, and there was no statistical difference between different regimens. Except Livial group, the other regimens effectively improved the score of HAMD （P〈0.01）. The score of HAMD in Paroxetine combined with Livial group and Jiawei Xiaoyao Pills group was increased, better than Paroxetine group （P〈0.05）, and there was no statistical difference between Paroxetine combined with Livial group and Jiawei Xiaoyao Pills group （P〈0.05）. There was no significant difference in TESS score between the first 3 groups, but they all had a higher score than Jiawei Xiaoyao Pills group, and the differences were statistically significant （P〈0.01）. Conclusion： Considering the side effects of paroxetine and latent, long-term risk of Livial, the regimen of Jiawei Xiaoyao Pills therapy deserved to be advocated in the clinical practice for the disease.

关 键 词：加味逍遥丸 围绝经期 情绪障碍 帕罗西汀 利维爱 激素替代疗法 

分 类 号：R271.116[医药卫生—中医妇科学]