黄连阿胶汤不同煎煮方法对慢性咽炎大鼠的影响  

Effects of different decoction methods of Huanglian Ejiao Decoction on rat model with chronic pharyngitis

作　　者：李凯[1] 牛乐[1] 贾利利[1] 张振凌[1] 

机构地区：[1]河南中医学院,郑州450046

出　　处：《中华中医药杂志》2014年第3期879-881,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：2010年中医药行业科研专项项目(No.201007010);河南中医学院博士基金项目(No.BSJJ2010-06)~~

摘　　要：目的:研究黄连阿胶汤不同煎煮方法对慢性咽炎大鼠作用的差异。方法:48只SD大鼠随机分为空白组、模型组、阳性组、传统煎煮组、机械常压组及机械高压组,每组8只。阴虚型慢性咽炎模型选用甲状腺片和氨水联合造模,采用酶免法测定三碘甲状腺原氨酸(T3)、甲状腺素(T4)、肿瘤坏死因子(TNF-α)和血管内皮生长因子(VEGF)含量,同时测定各实验组动物全血黏度、血浆黏度、全血还原黏度、红细胞压积、红细胞刚性、红细胞聚集指数等指标。结果:与空白组比较,模型组大鼠T3、T4、TNF-α、VEGF含量升高,具有显著性差异(P<0.01);不同煎煮组之间各项指标均无显著性差异。结论:黄连阿胶汤对慢性咽炎大鼠具有显著疗效;不同煎煮方法黄连阿胶汤没有明显差异。Objective： To study the effects of different decoction methods of Huanglian Ejiao Decoction on rat model with chronic pharyngitis. Methods： 48 SD rats were divided into blank control group, model group of chronic pharyngitis, the Qingyan tablet group, mechanical atmospheric pressure group, mechanical high-pressure group, 8 in each group. The rat model was established by thyroxine and ammonia. Contents of T3, T4, TNF-α and VEGF were measured by ELISA. The whole blood and plasma viscosity, whole blood reduced viscosity, hematocrit, erythrocyte rigidity, erythrocyte aggregation index were chosen as effect values. Results： Compared with blank group, contents of T3, T4, TNF-α and VEGF were higher in chronic pharyngitis group （P〈0.01）. Traditional decoction group, mechanical atmospheric pressure group and mechanical high-pressure group had no significant difference. Conclusion： Huanglian Ejiao Decoction is effective to chronic pharyngitis; and different decoction methods have no significant difference.

关 键 词：黄连阿胶汤 慢性咽炎 传统煎煮 机械常压煎煮 机械高压煎煮 

分 类 号：R276.1[医药卫生—中医五官科学]