32周前后发病重度子痫前期血常规和凝血及生化参数比较  

作　　者：王芳[1] 黎燕[1] 张立军[2] 夏俊霞[1] 

机构地区：[1]广东省深圳市人民医院产科,广东510080 [2]广东省深圳市人民医院检验科

出　　处：《当代医学》2014年第6期8-9,共2页Contemporary Medicine

摘　　要：目的探讨32周前、后发病的重度子痫前期（S-PE）血常规、凝血及部分生化参数的不同。方法回顾性分析65例20～31^＋6周发病（早发组）和44例52～36周（晚发组）发病S-PE患者外周血常规、血浆白蛋白（ALB）、血浆总蛋白（TB）、尿蛋白（Upro）、血清钙（ca）、凝血酶时间（TT）、凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、纤维蛋白原（Fib）、D二聚体、抗凝血酶Ⅲ活性（ATⅢ）参数。结果早发组PLT为（192．53土7053）×10^9、L，晚发组为（16970±4828）X10^9/L，两组比较差异有统计学意义（P〈O05）；早发组D二聚体为（580．61±1303．22）ug／L，晚发组为（29963±I2762I）μg/L，两组比较差异有统计学意义（P〈O05）；早发组ATⅢ活性为（8404±17.00）％，晚发组为（7325土1795）％，两组比较差异有统计学意义（p〈0.05）。而在凝血功能指标APTT、TT、FIb、生化指标ALB、TB、Upro及其他血常规指标WBC、MPV差异均无统计学意义。结论32周前发病的重度子痫前期比32周后发病的子痫前期高凝状态更明显，发病越早的重度子痫前期更需要抗凝治疗。Objective To compare the hematological, biochemical and coagulation parameters before and after 32 weeks＇ gestation with severe preeclampsia （S-PE）.Methods A retrospective study was performed in 63 S-PE patients 20-31＋6 weeks＇ gestation （early onset group）and 44 S-PE patients between 32-36 weeks＇ gestation（late onset gruop）. The following parameters were compared between the two groups： white blood cells （WBC）, platelet （PLT）, mean platelet volume （MPV）, Hemoglobin （HGB）, hematocrit （HCT）, albumin （ALB）, total plasma protein, urine protein （Upro）, serum calcium （Ca）, thrombin time （TT）, prothrombin time （PT）, Activated partial thromboplastin time （APTT）, Fibrinogen （Fib）, D-Dimer, Antithrombin g1 （AT Ⅲ）. ResuLts The values ofPLT, D-Dimer and ATI]I were （192.53±70.53）x109/L, （580.61±1303.22）p.g/L and （84.04±17.00）%, respectively in early onset group. The corresponding values of PLT, D-Dimer and ATⅢ were （169.70±48.28）x 109/L, （299.63±1276.21）μg/L and （73.25±17.95 ）% respectively in late onset group. There were significant different for these three parameters between the two groups. The were no significant difference between the two groups for the following parameters： APTT, TT, Fib, ALB,TB,Upro, WBC and MPV.Conciusion S-PE before 32 weeks＇ gestation is more likely to present thrombphilin state, which may suggest the necessity of anti-coagulation therapy in early-onset S-PE.

关 键 词：早发性重度子痫前期 血常规 血生化 凝血指标 

分 类 号：R714.244[医药卫生—妇产科学]