VCAM-1、VEGF及β2-MG在过敏性紫癜中含量及其相关性  

The Change of Plasm Level of VCAM-1, VEGF and β2-MG in Children Anaphylactoid Purpura

作　　者：傅卓[1] 任少敏[1] 高晓峰[1] 杨光路[1] 李筱贺[2] 

机构地区：[1]内蒙古医科大学附属医院儿科,内蒙古呼和浩特010050 [2]内蒙古医科大学基础医学院人体解剖教研室,内蒙古呼和浩特010110

出　　处：《现代生物医学进展》2014年第5期837-840,849,共5页Progress in Modern Biomedicine

基　　金：内蒙古自治区卫生厅资助项目(2006022);内蒙古自然科学基金项目(2012MS1117);内蒙古医学院博士科研启动基金项目(BSJJ2011007)

摘　　要：目的:探讨紫癜性肾炎(APN)、过敏性紫癜(AP)和正常对照组血中血管细胞粘附分子-1(VCAM-1)、血管内皮生长因子(VEGF)和β2-微球蛋白(β2-MG)的含量变化,以及AP中VCAM-1、VEGF和β2-MG之间的相关性,以证实VCAM-1和VEGF参与了AP的部分发病机制。方法:采用ELISA法,检测APN组22例,AP组28例及健康儿童30名为正常对照组的血浆中VCAM-1和VEGF的含量。生化分析仪检测三组儿童的血β2-MG。比较APN组、AP组和正常对照组之间VCAM-1、VEGF和β2-MG的差异,及三者间的相关性分析。结果:血浆VCAM-1含量、VEGF含量和血中β2-MG含量均APN组>AP组>正常对照组,差异均有统计学意义(P<0.01);在APN和AP组中,血浆VCAM-1、VEGF和血β2-MG散点图呈线性趋势,均呈正相关。三者间相关性分析均r>0(P<0.01)。结论:儿童AP血浆VCAM-1、VEGF和血β2-MG含量升高,APN均比AP更高,且三者间均呈正相关。示三者均参与了AP的部分发病机制。Objective： To explore the relationship between plasm level of VCAM-1 ,VEGF and β2-MG in children anaphylactoid purpura （AP）. Methods： The concentrations of VCAM-1, VEGF and β2-MG in plasm were detected with enzyme-linked immunosorbe- nt assay in ninety children with AP and thirty healthy children. The serum Cr, β2-MG and 24h urine protein quantitative were detected with biochemical analyzer. Results： The level of VCAM-1, VEGF and β2-MG in acute phase of AP children was significantly higher than those in remission and normal control group; The level of VCAM-1, VEGF and β2-MG in acute phase of APN group and AP group were linearity and positive correlationr r〉0（P〈0.01 ） Conclusion： The concentrations ofVCAM-1 ,VEGF and β2-MG in serum increases markedly in acute phase of AP,those in APN are higher than in AP. and can reflect the severity of the disease.

关 键 词：过敏性紫癜 紫癜性肾炎 儿童 血管细胞粘附分子-1 血管内皮生长因子 Β2-微球蛋白 

分 类 号：R692.34[医药卫生—泌尿科学] R554.6[医药卫生—外科学]