干细胞治疗周围神经损伤研究进展  

Research Progress in Stem Cell Therapy of Peripheral Nerve Injury

作　　者：王海涛[1] 朴太奎[1] 马志强[1] 王彦龙[1] 孔祥龙[1] 李兆鹏[1] 郑峰[1] 刘建宇[1] 

机构地区：[1]哈尔滨医科大学第二附属医院骨一科,黑龙江哈尔滨150081

出　　处：《现代生物医学进展》2014年第5期978-981,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81272015)

摘　　要：周围神经损伤是临床常见的疾病。损伤后神经的修复和再生是复杂又漫长的过程。严重的神经损伤其预后效果并不令人满意,相应支配区域的功能难以恢复,这给患者及家人带来了极大的痛苦。因此如何更好的对周围神经损伤进行治疗一直是医学界的难题。在神经修复机制的研究中,科学家发现施万细胞对周围神经的修复和再生起到了非常重要的作用,但获取和扩增的困难限制了其临床的应用。随着生物医学的发展,人们把目光投向了干细胞,经实验发现干细胞不仅具有旺盛的增殖能力,而且可以分化为神经系细胞,还能分泌相关的神经营养因子促进神经的修复和再生,这为周围神经损伤后的治疗带来了新的希望。本文就近些年来应用于修复周围神经的干细胞及促进修复机制的研究做以综述。Peripheral nerve injury is a common clinical disease. The process of nerve repair and regeneration is complicated and lengthy. The prognostic effect is unsatisfactory since the nerve function of related control area cannot restoration after severe nerve damage. These cause great suffering to the patients and their families. Thus how to treat peripheral nerve injury better is still a major medical problem. In the studies of nerve repair mechanism, scientists found that stem cells plays a major role in the process of nerve repair and regeneration, but it is limited for clinical application because cells harvest and amplification is difficult. With the development of biomedicine, scientists have set their sights on stem cells. It is found that stem cells have the ability of self-renewal and differentiation potential of neural lineage cells. This brings us a new hopes for therapy of peripheral nerve injury. The role of stem cells and its mechanism on repair and regeneration peripheral nerve in recent years are reviewed in this paper.

关 键 词：干细胞 周围神经损伤 修复 再生 

分 类 号：Q813[生物学—生物工程]