致炎细胞因子在骨性关节炎病理生理中的作用  

Role of Proinflammatory Cytokines in the Pathophysiology of Osteoarthritis

作　　者：张洪亮[1] 王文波[1] 李明宇[1] 李进取[1] 史雪峰[1] 

机构地区：[1]哈尔滨医科大学附属第一临床医学院骨科,黑龙江哈尔滨150001

出　　处：《现代生物医学进展》2014年第5期989-992,共4页Progress in Modern Biomedicine

摘　　要：骨性关节炎(OA)是一种退行性病变,表现为关节软骨破坏,关节边缘骨赘形成,并伴有不同程度滑膜炎症,其病因学和发病机制还不是十分清楚。研究表明致炎细胞因子在骨性关节炎病发病的病理生理过程中起着重要的作用。本综述讨论目前关于致炎细胞因子在OA病理生理中的作用机制以及抗致炎细胞因子在治疗OA中的新进展。Osteoarthritis （OA） is associated with cartilage destruction, subchondral bone remodeling and inflammation of the synovial membrane. However, this debilitating disease are poorly understood. Secreted inflammatory molecules, such as proinflammatory cytokines, are among the critical mediators of the disturbed processes implicated in OA pathophysiology. This Review discusses the current knowledge regarding the role of proinflammatory cytokines in the pathophysiology of OA and addresses the potential of anti-cytokine therapy in the treatment of this disease.

关 键 词：骨性关节炎 细胞因子 白介素 肿瘤坏死因子 抗致炎细胞因子 

分 类 号：R684.3[医药卫生—骨科学]