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机构地区:[1]南方医科大学珠江医院神经内科,广东广州510280 [2]南方医科大学珠江医院心内科,广东广州510280
出 处:《今日药学》2014年第1期4-6,共3页Pharmacy Today
基 金:广东省药学会基金(编号:2011X19)
摘 要:目的研究左旋氨氯地平对局灶性脑缺血小鼠模型脑梗死体积的影响,探讨左旋氨氯地平对缺血性脑梗死的神经保护作用。方法制备小鼠大脑中动脉脑缺血再灌模型,根据是否使用左旋氨氯地平随机分为3组:左旋氨氯地平缺血前处理组,缺血生理盐水处理组,假手术对照组;多普勒超声血流仪监测梗死侧脑区的脑血流量;TTC染色检测脑梗死体积。结果与缺血生理盐水处理组相比较,左旋氨氯地平缺血前处理组梗死侧脑区的脑血流量没有明显变化,而脑梗死体积较小,差异有统计学意义(P<0.05)。结论使用左旋氨氯地平可能有助于减少缺血性脑梗死体积。Objective To explore the effect of Levamlodipine on infarct volume in mouse model of focal cerebral ischemia. Methods Male C57BL/6 mice were subjected to transient middle cerebral artery occlusion (MCAO) by a nylon thread. Animals were divided into 3 groups: sham-treated, saline control, and Levamlodipine group. In the Levamlodipine and saline control groups, mices were pretreated with Levamlodipine (1.5 mg/kg ) and saline control before MCAO. Mites were killed 24 h after MCAO. Cerebral blood flow and infarct volume were investigated. Results There was no significant difference of cerebral blood flow among groups. Levamlodipine group showed more marked reduction of infarct volume. Conclusion levamlodipine showed a neuroprotective effect in ischemic brain.
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