micro-CT法观测雌性小鼠股骨骨参数的分析  

Analysis on Femur Bone Parameters in Female Mice by Using Micro-CT

作　　者：耿沁[1] 朱淼鑫[1] 孙磊[1] 崔永奇[1] 孔韩卫[1] 姚明[1] 刘蕾[1] 

机构地区：[1]上海市肿瘤研究所癌基因及相关基因国家重点实验室,上海200032

出　　处：《实验动物与比较医学》2014年第1期46-49,共4页Laboratory Animal and Comparative Medicine

基　　金：上海市科委创新行动计划（11140902100）

摘　　要：目的 利用小动物CT（micro-CT）收集正常雌性BALB/c-nu/nu小鼠与BALB/c小鼠股骨的影像学数据.方法 BALB/c-nu/nu小鼠与BALB/c小鼠各15只,雌性,10～12周龄,取股骨后用micro-CT进行扫描,将得到的数据进行系统分析.结果 成功收集了正常雌性BALB/c-nu/nu小鼠与BALB/c小鼠股骨的CT影像学数据.通过数据分析,发现两者在皮质骨相对骨体积上具有显著差异,在骨小梁相对骨体积、骨表面积与组织体积比值和骨密度也有显著差异.结论 micro-CT可以对雌性小鼠股骨的各项参数进行定量分析.Objective To obtain femur bone datas about female BALB/c-nu/nu and BALB/c mice by using micro-CT. Methods The femur from fifteen female nude mice with BALB/c background and BALB/c mice respectively, aged 10-12weeks, were scanned with micro-CT. Results The parameters of female BALB/c-nu/nu and BALB/c mice femur bone were detected by using micro-CT, there are differences of femur bone in some parameters between BALB/c-nu/nu and BALB/c mice. In the vortical bone, there is significant difference in BV/TV. In the trabecular bone, BV/TV, BS/TV and BMD have significant difference. Conclusions Micro-CT can be used for quantitative analysis of mice femur bone parameters.

关 键 词：股骨 小鼠 雌性 

分 类 号：Q95-33[生物学—动物学]