非高密度脂蛋白胆固醇是评价血脂异常患者心血管风险的指标  

Non-high density lipoprotein-cholesterol is an indicator to assess cardiovascular risk for subjects with dyslipidemia

作　　者：张鹏睿[1,2] 徐援[2] 王广[2] 杨金奎[1] 

机构地区：[1]首都医科大学附属北京同仁医院内分泌科,北京100005 [2]首都医科大学附属北京朝阳医院内分泌科,北京100020

出　　处：《首都医科大学学报》2014年第1期73-76,共4页Journal of Capital Medical University

摘　　要：目的证实无论患者是否有血糖升高,非高密度脂蛋白胆固醇(non-high density lipoprotein-cholesterol,non-HDL-C)都是不弱于低密度脂蛋白胆固醇(low density lipoprotein-cholesterol,LDL-C)的评估血脂异常患者患者心血管病风险和降脂治疗疗效的有效临床指标。方法选取2007年首都医科大学附属北京同仁医院内分泌科大规模临床调查患者6 341例,检测总胆固醇(total cholesterol,TC)、高密度脂蛋白胆固醇(high density lipoprotein-cholesterol,LDL-C)、三酰甘油(triglyceride,TG),并且计算non-HDL-C(non-HDL-C等于TC-HDL-C)。根据空腹血糖高低分为血糖正常组和血糖升高组,比较两组中血脂异常患者的各项血脂指标;以non-HDL-C为纵轴,分别以LDL-C和TG为横轴作散点图。结果血糖升高组的TC、LDL-C、HDL-C、TG、non-HDL-C较血糖正常组均明显升高。作non-HDL-C与LDL-C和TG相关性的散点图并作趋势拟合线后,发现non-HDL-C与LDL-C、TG均呈线性正相关。结论 non-HDL-C是一项评估血脂异常患者心血管病风险和降脂治疗疗效的有效临床指标。Objective To confirm that non-high density lipoprotein-cholesterol （non-HDL-C） is an effective clinical indicator to assess the cardiovascular disease （CVD） risk and lipid-lowering therapy regardless of glucose level. Methods A total of 6 341 subjects were selected from large-scale clinical survey of the Department of Endocrinology, Beijing Tongren Hospital in 2007. Fasting blood samples were collected from each subject and were tested for total cholesterol （ TC）, low density lipoprotein cholesterol （ LDL-C）, HDL- C, triglycefide （TG） and non-HDL-C was calculated by subtracting TC from HDL-C. The subjects were divided into euglycemia group and hyperglycemia group according to fasting glucose level and the other parameters of the 2 groups were compared. Results TC, LDL- C, HDL-C, TG and non-HDL-C in hyperglycemia group were higher than that in euglyeemia group. A linear positive correlation was found between non-HDL-C and LDL-C, non-HDL-C and TG. Conclusion non-HDL-C is an effective clinical indicator to assess the cardiovascular decease risk and lipid-lowering therapy.

关 键 词：非高密度脂蛋白胆固醇 低密度脂蛋白胆固醇 血脂异常 血糖升高 

分 类 号：R543[医药卫生—心血管疾病]