抗HIV-1基因治疗新进展  

Recent progress in the gene therapies against HIV-1

作　　者：田雅茹[1] 焦艳梅[1] 张彤[1] 吴昊[1] 

机构地区：[1]首都医科大学附属北京佑安医院感染中心,北京100069

出　　处：《首都医科大学学报》2014年第1期101-107,共7页Journal of Capital Medical University

基　　金："十二五"国家科技支撑计划重大项目(2012ZX10001-006);北京市艾滋病研究重点实验室(BZ0089)~~

摘　　要：虽然高效抗反转录病毒治疗(highly active anti-retroviral therapy,HAART)取得了显著的成果,但是抗人类免疫缺陷病毒(human immunodeficiency virus,HIV)药物治疗仍有其局限性(如引起毒素蓄积和病毒突变)。基因治疗在理论上具有较好的抗HIV能力,可以通过持续干扰病毒复制,提供了阻止HIV进行性感染的希望。本篇综述主要探讨当前多种基因治疗策略及其最新进展。Highly active antiretroviral therapy （HAART） has achieved significant success, but anti-HIV drug treatment still has its limitation, such as causing drug toxicity and viral-escape mutants. Gene therapy has better ability of anti-HIV in theory. It offers the promise of preventing progressive HIV infection by sustained interference with viral replication. Gene-targeting strategies are being developed with RNA-based agents, such as ribozyme, antisense, RNA aptamers and small interfering RNA, and protein-based agents, such as the mutant HIV Rev protein M10, fusion inhibitors and zinc-finger nucleases. This review mainly discusses the various gene therapy strategies and recent progress. Many of these strategies are being tested in ongoing and planned clinical trials.

关 键 词：获得性免疫缺陷综合征 人类免疫缺陷病毒1型 基因疗法 慢病毒载体 

分 类 号：R512.91[医药卫生—内科学]