微波辐射技术在药物制剂领域的应用  

Application of microwave irradiation technology to the field of pharmaceutics

作　　者：张雪冰[1,2] 时念秋[3] 杨志强[2] 王杏林[2] 

机构地区：[1]天津中医药大学,天津300193 [2]天津药物研究院释药技术与药代动力学国家重点实验室,天津300193 [3]吉林医药学院,吉林吉林132013

出　　处：《药学学报》2014年第3期303-309,共7页Acta Pharmaceutica Sinica

基　　金：国家重点基础研究发展计划(973计划)资助项目(2012CB724002)

摘　　要：微波是一种可以穿透物质并在物质内部直接转化为热能的能源。微波对物质加热的程度依赖物质的介电性质,高介电损耗的物质更容易与微波电磁场达到共振,从而更高效地吸收微波。由于独特的加热机制,微波辐射技术可以诱导药物与聚合物的相互作用、改变药物的溶出特征,并且微波辐射技术具有提高产品质量、节能和节省时间等优势。本文总结了微波辐射技术的特点及微波辐射技术在制剂新技术、制剂过程中应用的研究进展,旨在为药物制剂领域加热干燥提供新思路。Microwaves can be directly transformed into heat inside materials because of their ability of penetrating into any substance. The degree that materials are heated depends on their dielectric properties. Materials with high dielectric loss are more easily to reach a resonant state by microwaves field, then microwaves can be absorbed efficiently. Microwave irradiation technique with the unique heating mechanisms could induce drug-polymer interaction and change the properties of dissolution. Many benefits such as improving product quality, increasing energy efficiency and reducing times can be obtained by microwaves. This paper summarized characteristics of the microwave irradiation technique, new preparation techniques and formulation process in pharmaceutical industry by microwave irradiation technology. The microwave technology provides a new clue for heating and drying in the field ofpharmaceutics.

关 键 词：微波辐射 介电损耗 加热机制 制剂新技术 制剂过程 溶出 

分 类 号：R943[医药卫生—药剂学]