非那雄胺1mg/d治疗杭州地区184例男性雄激素性秃发患者的疗效观察  

Evaluation of efficacy and safety of finasteride 1 mg/d in the treatment of androgenetic alopecia in Hangzhou region

作　　者：刘晓艳[1] 吴银华[1] 王艳[1] 徐兵[1] 方德仁[1] 方红[1] 

机构地区：[1]浙江大学第一医院皮肤科,浙江杭州310003

出　　处：《临床皮肤科杂志》2014年第3期173-175,共3页Journal of Clinical Dermatology

基　　金：浙江省卫生厅科研基金(2007B65)资助项目

摘　　要：目的:评价杭州地区男性雄激素性秃发(androgenetic alopecia,AGA)患者服用1 mg/d非那雄胺的疗效和安全性。方法:收集2010年1月—2011年12月在该院脱发专科就诊且服用1 mg/d非那雄胺的184例男性AGA患者的临床资料和临床照片:临床疗效评估采用患者自我评估与医生照片评估相结合,以标准化的7级量表评定疗效,并进行临床疗效和临床性征相关性分析。结果:1 mg/d非那雄胺治疗杭州地区男性AGA患者的总有效率为75.00%,其中轻度改善、中度改善和明显改善分别为38.04%、23.37%和13.59%。临床疗效与脱发部位、脱发等级和治疗时间有关,而与发病年龄和发病病程无明显相关。治疗患者中仅4例出现一过性轻度不良反应。结论:口服1 mg/d非那雄胺可有效治疗男性AGA,且耐受性好。Objective： To evaluate the efficacy and safety of finasteride 1 mg/d on male androgenetic alopecia （AGA） patients in Hangzhou Region. Methods： Clinical data and photographs of male AGA treated with finasteride 1 mg/day were collected from January 2010 to December 2011 at our clinic. The efficacy was evaluated by patients＇ self-assessments and doctors＇ photograph- ic assessments with the standardized 7-point rating scale. The relationship between clinical efficacy and clinic characteristics was also analyzed. Results： The total effective rate was 75% in male AGA treated with finasteride 1 rag/day. The rates of slight, mod- erate, and significant improvement were 38.04%, 23.37% and 13.59%, respectively. The response rates were associated with in- volved sites, disease severity and duration of treatment, and were independent of age and course. Mild adverse reactions occmTed in 4 cases. Conclusion： Oral finasteride 1 mg/d is effective for male AGA without considerable side effects.

关 键 词：秃发 雄激素性 非那雄胺 疗效 杭州地区 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]