问号钩端螺旋体重要蛋白研究进展  

Research process on significant proteins of Leptospira interrogans

作　　者：曹志强[1] 蒋秀高[1] 张翠彩[1] 

机构地区：[1]中国疾病预防控制中心传染病预防控制所,北京102206

出　　处：《中国人兽共患病学报》2014年第2期180-185,共6页Chinese Journal of Zoonoses

摘　　要：钩端螺旋体(简称钩体)外膜蛋白(outer membrane proteins,OMPs)位于钩体表面,与宿主细胞直接接触,是重要的蛋白抗原。钩体OMPs是抗体和补体的作用部位,在致病和免疫应答过程中起重要的作用。一些钩体的外膜蛋白或外膜脂蛋白被证实有良好的抗原性和高度的基因保守性,其抗体具有广泛的交叉免疫凝集作用,这使得新一代基因工程疫苗开发成为可能。本文主要对钩端螺旋体几种重要OMPs的细胞定位、基因结构、在感染动物中的表达状态、在免疫保护中的作用等进行综述。The outer membrane proteins of Leptospira, which located in the surface of outer membrane, making direct contact with host cell, are significant protein antigens. The OMPs play an important role in the pathopoiesia and immune re- sponse by reaction with antibodies and complements. Some OMPS, which have good antigenicity and gene conservatism and of which the antibody could extensively agglutinate, thus makes a new generation of gene vaccine possible. This review surveys some main types of outer membrane proteins（OMPs） of Leptospira and summarize their cellular localizations, genetic struc- tures, expressed status and the roles in immune protection in infectious animals.

关 键 词：问号钩端螺旋体属 细菌外膜蛋白类 抗原 

分 类 号：R377[医药卫生—病原生物学]