热休克蛋白90α在女性巨乳症中的表达及意义  

Expression of heat shock protein 90α in mammary hypertrophy and its significance

作　　者：徐晨[1] 栗勇[1] 王钠[1] 雷鸣[1] 

机构地区：[1]西安,第四军医大学西京医院,整形外科,陕西710032

出　　处：《中国美容整形外科杂志》2014年第3期185-188,共4页Chinese Journal of Aesthetic and Plastic Surgery

摘　　要：目的 探讨巨乳中的热休克蛋白90α的表达及定位,并分析其在巨乳症发病中的作用机制.方法 采用免疫组化法测定40例巨乳乳腺组织及40例正常体积乳腺组织中热休克蛋白90α的表达及定位.结果 热休克蛋白90α在巨乳乳腺组织中的表达率为87.5%,在正常体积乳房乳腺组织中的表达率为22.5%.两者差异具有统计学意义.结论 热休克蛋白90α在巨乳症乳腺组织中呈高表达,提示热休克蛋白90α可能参与了巨乳症的发生及发展.Objective To investigate expressions of Hsp90α and its position, analyzing the mechanism of action in formation of mammary hypertrophy. Methods Tissues （ 80 samples） were collected from 40 pa- tients with mammary hypertrophy and 40 patients with normal breast and the expression of Hsp90c~ and its posi- tion were determined by immunohistochemistry. Results The protein level of Hsp90α was significantly in- creased in mammary hypertrophy tissues （87.5%） compared with that in normal tissues （22.5%）. Conclu- sion Hsp90α may plays an important role in the development of mammary hypertrophy.

关 键 词：巨乳症 热休克蛋白90Α 组织增殖 

分 类 号：R655.8[医药卫生—外科学]