IgA肾病患者血清6种常见过敏食物特异性抗体的检测  

Detection of serum food specific antibodies of 6 common foods in patients with IgA nephropathy

作　　者：周朝敏[1] 刘志刚[2] 眭维国[3] 谷东风[1] 李永强[1] 邹和群[1] 

机构地区：[1]南方医科大学第三附属医院肾内科泌尿疾病研究所,广东广州510630 [2]深圳大学医学院过敏反应与免疫学研究所,广东深圳518060 [3]中国人民解放军第181中心医院全军肾移植与透析治疗中心,广西桂林541002

出　　处：《南方医科大学学报》2014年第3期419-422,共4页Journal of Southern Medical University

基　　金：深圳市重点实验室组建项目(SW201110010);深圳市科技计划基础研究重点项目(JC201005250073A)

摘　　要：目的初步探讨6种常见过敏食物的主要过敏蛋白与IgA肾病发病的关系。方法采用ELISA双抗体夹心法检测并比较31例IgA肾病患者及80例健康体检者血清中6种常见过敏食物的主要过敏蛋白特异性的IgA1、IgG及IgE水平,并对所有病人进行食物过敏情况问卷调查,观察多种食物抗体水平均明显升高的患者的临床特征。结果 IgA肾病组患者血清中6种常见过敏食物的主要过敏蛋白特异性的IgA1及IgG水平均显著高于健康对照组(P<0.05)。两组中均未检测到食物特异性的IgE。所有病人均无明确的食物过敏史。多种食物(大于4种)特异性IgG抗体水平均明显升高的患者均有蛋白尿。结论某些食物尤其是高致敏性食物在IgA肾病的发病及进程中可能伴有重要角色。Objective To explore the relationship between the major allergens of 6 common allergic foods and IgA nephropathy. Methods A sensitive sandwich enzyme-linked immunosorbent assay （ELISA） was used to detect the serum levels of food-specific IgA1, IgG and IgE in 31 patients with IgA nephropathy and 80 healthy volunteers. All the patients were examined for a history of food allergy using a questionnaire. Results Serum levels of IgA1 and IgG against the major allergens of the 6 common allergic foods were significantly higher in patients with IgA nephropathy than in healthy volunteers （P＆lt;0.05）. There was no detectable food-specific IgE antibodies in the two groups. No patients had a clear history of food allergy. All the patients with increased IgG levels specific to 4 or more foods simultaneously had proteinuria. Conclusion Some foods especially the highly allergic ones may participate in the pathogenesis and progression of IgA nephropathy.

关 键 词：IGA肾病 食物抗原 过敏原 

分 类 号：R692.3[医药卫生—泌尿科学]